Related Products of 109-08-0, A common heterocyclic compound, 109-08-0, name is 2-Methylpyrazine, molecular formula is C5H6N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
In a 500 mL reactor, 94.1 g (1 mol) of 2-methylpyrazine was added.0.2 g (0.0016 mol) of ferrous chloride, and 225 g (1.99 mol) of hydrogen peroxide having a mass concentration of 30percent was added dropwise at 30 ° C.After the completion of the dropwise addition for 4 hours, the temperature was raised to 50 ° C, and 40 g (2.35 mol) of ammonia gas was introduced. After the completion of the ammonia gas, the temperature was maintained for 7 hours.After cooling to 10 ° C, the crude product was filtered.The crude product was recrystallized from 3 times by weight of water to give 117 g of the desired pyrazinamide in a yield of 95percent.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.