Synthetic Route of 1174321-06-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1174321-06-2, name is 5-(Difluoromethyl)pyrazine-2-carboxylic acid belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.
1) Synthesis of Compound F-21: Compound F-19 (18 mg, 0.04 mmol) was dissolved in dichloromethane (3 mL),1H-benzotriazol-1-yloxytripyrrolidinylhexafluorophosphate (PyBOP) (57 mg, 0.1 mmol), diisopropylethylamine (21.6 muL, 0.13 mmol) was added,5-Difluoromethylpyrazine-2-carboxylic acid (16 mg, 0.09 mmol), reacted overnight at room temperature;TLC showed complete reaction of the raw materials, adding dichloromethane (5mL), and then saturated organic saline to wash the organic phase, the organic phase was dried by spin-drying the column product 23mg;Suggest an edit
The synthetic route of 5-(Difluoromethyl)pyrazine-2-carboxylic acid has been constantly updated, and we look forward to future research findings.