Adding a certain compound to certain chemical reactions, such as: 21948-70-9, name is 2-Methylthiopyrazine, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 21948-70-9, Formula: C5H6N2S
General procedure: In the glovebox, aryl methyl sulfane (0.5 mmol), alkyl thiol (2.0 equiv, 1 .0 mmol),LiHMDS (1 .3 ml, 1.0 M in toluene), and SingaCycle Al (0.4 mol%, 0.4 ml, 0.005 Min toluene) were added into an oven-dried 8 ml vial with a magnetic stirring bar, followed by addition of toluene (0.3 ml). The vial was sealed and removed out of the glovebox and heated to 100 00. After 12 h, the vial was cooled to room temperature. The reaction was diluted with ethyl acetate and washed withsaturated NaOH solution. The aqueous phase was extracted with ethyl acetate 3 times. The collected organic phases were dried over anhydrous Na2504. The solvent was removed under reduced pressure and the residue was purified by flash column chromatography to give the desired product.
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