Electric Literature of 1458-18-0, The chemical industry reduces the impact on the environment during synthesis 1458-18-0, name is Methyl 3-amino-5,6-dichloropyrazine-2-carboxylate, I believe this compound will play a more active role in future production and life.
A mixture of methyl 3-amino-5, 6-dichloropyrazine-2-carboxylate (1 g, 4.5 nMol, 1 equiv) and (5-methylfuran-2-yl) boronic acid (0.6 g, 4.8 nMol) and Pd (dppf) Cl 2 (0.3 g, 0.5 nMol) and Na 2CO 3 (1.0 g, 9.0 nMol) in dioxane/H 2O (40 mL) was stirred for 4 hours at 90 under nitrogen atmosphere. The resulted mixture was filtered, the filter cake was washed with DCM: MeOH (1: 1) (3 x 10 mL) . The filtrate was extracted with CH 2Cl 2 (3 x 10 mL) . Then the organic layer was dried by Na 2SO 4, and the solution concentrated under reduced pressure. The crude product was purified by Prep-HPLC with the following conditions (CH 2Cl 2: EtOAc (1: 1) ) to afford methyl 6-chloro-3-methyl-5- (5-methylfuran-3-yl) pyrazine-2-carboxylate (125 mg, 7.1%) as a yellow solid. LCMS: m/z (ESI) , [M+H] + = 268.2.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 3-amino-5,6-dichloropyrazine-2-carboxylate, other downstream synthetic routes, hurry up and to see.