Related Products of 77112-52-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 77112-52-8 name is Ethyl imidazo[1,2-a]pyrazine-2-carboxylate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
A mixture of lithium chloride monohydrate (6.50g, 0.156mol) was added to Compound 84 (9.73g, 0.05mol) [Reference Preparation WO2009090055] in ethanol / water (400ml / 100ml), stirred at room temperature 8 hours, the solvent was distilled off under reduced pressure, under ice-cooling with a 1N aqueous hydrochloric acid solution was adjusted to PH 3-4, and the precipitated solid was filtered, washed with acetone and dichloromethane, respectively cake, 50 C and dried under reduced pressure to give a pale pink solid powder compound 85, a total of 7.69g (9.4mmol), yield 93.7%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Ethyl imidazo[1,2-a]pyrazine-2-carboxylate, and friends who are interested can also refer to it.