Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 41270-66-0, name is 5-Chloro-2,3-diphenylpyrazine, A new synthetic method of this compound is introduced below., HPLC of Formula: C16H11ClN2
[131] Step 1. 2-(4-((5,6-Diphenylpyrazin-2-yl)(perdeutero-propan-2-yl)amino)butan-l-ol(12c). To a solution of commercially available 5-chloro-2,3-diphenylpyrazine (10) (0.70 g, 2.62 mmol) in NMP (2 mL), was added d7-aminoalcohol lie (0.54 g, 3.93 mmol, 1.5 equiv, prepared as described in Example 7). The reaction vessel was sealed and heated to 190 0C for 15 hours, then cooled to ambient temperature. The mixture was diluted with ice water and extracted with Et2O (3 x 20 rnL). The combined organic layers were washed successively with water and brine. The resulting organic layer was dried (MgSO4), filtered and concentrated in vacuo. The resulting residue was purified by column chromatography (SiO2, 30-50% EtOAc/heptane) to afford 12c (0.20 g, 21%). MS (M+H): 369.2.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.