Related Products of 313339-92-3,Some common heterocyclic compound, 313339-92-3, name is 3,5-Dichloropyrazine-2-carbonitrile, molecular formula is C5HCl2N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
3,5-Dichloropyrazine-2-carbonitrile (500 mg, 2.9 mmol), tert-butyl ((410 methylpiperidin-4-yl)methyl)carbamate hydrochloride (655 mg, 2.9 mmol) and diisopropyl ethylamine (1.5 mL, 287 11mol) were combined in dimethyl sulfoxide (10 mL) and stirred at 70 oc for 1 h. LCMS indicated ~44% of desired product formed. The reaction mixture was diluted with ethyl acetate (100 mL), washed with water (50 mL x 4), brine (30 mL), dried over anhydrous sodium sulfate, filtered, concentrated in vacuo before being purified by flash silica 15 gel chromatography (eluting with ethyl acetate: petroleum ether= 0:100 to 50: 100) to afford tert-buty 1 ( (1-( 6-chloro-5-cyanopyrazin-2-y 1)-4-methy lpiperidin-4-y l)methy )carbamate (900. 0 mg, 86% yield) as a yellow solid.
The synthetic route of 313339-92-3 has been constantly updated, and we look forward to future research findings.