Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 6966-01-4, name is Methyl 3-amino-6-bromopyrazine-2-carboxylate, A new synthetic method of this compound is introduced below., Application In Synthesis of Methyl 3-amino-6-bromopyrazine-2-carboxylate
General Method 9Preparation of (S)-(2-(3-chlorobenzyl)pyrrolidin-1-yl)(3-hydroxy-6-phenylpyrazin-2-yl)methanone (9-6); Step 1: Methyl 3-amino-6-bromopyrazine-2-carboxylate 9-1 (0.85 g, 3.68 mmol), phenylboronic acid (0.56 g, 3.68 mmol) and 2M aqueous sodium carbonate (7.4 mL) were mixed with toluene (8 mL) and methanol (2 mL). Palladium tetrakis(triphenylphosphine) (427 mg, 0.37 mmol) was added. The mixture was degassed and heated under nitrogen at 85 C. for 4 h. The reaction mixture was cooled to room temperature and filtered through a pad of Celite. The filtrate was concentrated and residue was separated by column chromatography (silica gel, gradient elution with DCM to 5% MeOH-DCM), to give desired product 9-2 as a yellow solid.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.