Related Products of 179323-60-5,Some common heterocyclic compound, 179323-60-5, name is 1-(Pyrazin-2-yl)ethanamine, molecular formula is C6H9N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step 2 5-Iodo-4′-methyl-biphenyl-3-carboxylic acid-1-pyrazin-2-yl-ethyl)-amideThe 5-iodo-4′-methyl-biphenyl-3-carboxylic acid from step 1, together with 1-pyrazin-2-yl-ethylamine (0.15 mL, excess), HOAt (10 mg, catalytic amount), NMM (0.4 mL) and EDCI (400 mg) were added to DMF (6 mL). The reaction mixture was stirred overnight at room temperature, then partitioned between water and ethyl acetate. The organic layer was concentrated under reduced pressure and the resulting residue was purified by preparative thin layer chromatography (5% MeOH in dichloromethane) to give 340 mg (95% yield overall) of 5-iodo-4′-methyl-biphenyl-3-carboxylic acid 1-pyrazin-2-yl-ethyl)-amide.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-(Pyrazin-2-yl)ethanamine, its application will become more common.