Month: April 2021

Application of 23787-80-6, These common heterocyclic compound, 23787-80-6, name is 1-(3-Methylpyrazin-2-yl)ethanone, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: General procedure: 8-Hydrazinocaffeine (3) (112 mg;0.5 mmol) and carbonyl compound (1 mmol; 2 eq.) were mixedin ethanol (20 mL, containing 0.2 mL of acetic acid) and heated at 75 omicronC for 3 days. After cooling down, reaction mixture was evaporatedto dryness and solid residue was suspended in diethyl ether(50 mL), filtered off, washed with additional portion of diethylether (3 25 mL) and dried in vacuo at 50 C to obtain the hydrazone.

Statistics shows that 1-(3-Methylpyrazin-2-yl)ethanone is playing an increasingly important role. we look forward to future research findings about 23787-80-6.

Reference of 126069-70-3, A common heterocyclic compound, 126069-70-3, name is 2-(Trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine, molecular formula is C7H8F3N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

2-(Trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1 ,2-a]pyrazine (0.096 g, 0.5 mmol, intermediate 4) and diethylaminomethyl polystyrene (0.469 g, 1.500 mmol) were slurried in dichloromethane (DCM) (5 ml). 2,4-Dichlorobenzoyl chloride (0.084 ml, 0.600 mmol) was added and the mixture stirred at room temperature for 24 h. The resin was filtered, washed with dichloromethane and the filtrate concentrated in vacuo to afford crude product which was purified by flash chromatography (Biotage SP4, 25+S, eluting with a 0-100% gradient of ethyl acetate/iso-hexane) to afford 7- [(2,4-dichlorophenyl)carbonyl]-2-(trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1 ,2- a]pyrazine (0.178 g, 0.489 mmol, 98 % yield).LC/MS [M+H]+ = 364, 366, 368, retention time = 2.30 minutes (5 minute method).

The synthetic route of 126069-70-3 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1379338-74-5, name is 5,7-Dichloropyrido[3,4-b]pyrazine, A new synthetic method of this compound is introduced below., category: Pyrazines

Intermediate 37: 1,1-dimethylethyl 3-{[(7-chloropyrido[3,4-b]pyrazin-5-yl)amino]methyl}-4,4-difluoro-1-piperidinecarboxylate (Isomer 2) 5,7-Dichloropyrido[3,4-b]pyrazine (620 mg, 3.10 mmol) was dissolved in N-methyl-2-pyrrolidinone (NMP) (5 mL) and to this was added DIPEA (0.601 mL, 4.65 mmol) and 1,1-dimethylethyl 3-(aminomethyl)-4,4-difluoro-1-piperidinecarboxylate (776 mg, 3.10 mmol). This was heated in a microwave at 130 C. for 30 min. The reaction mixture was partitioned between ethyl acetate and water. The aqueous was re-extracted twice with ethyl acetate and the combined organic layers washed with brine, dried over a hydrophobic frit and concentrated in vacuo to yield a brown oil. It was dissolved in DCM and passed through silica (100 g) eluting with a 10-50% ethyl acetate in cyclohexane gradient. Appropriate fractions were combined and concentrated in vacuo to yield the title compound as a yellow solid, 1.0 g. Chiral separation was achieved (Sample preparation: Sample dissolved in ethanol (30 ml) sonicating and heating with air gun as required. 4-5 ml injections were then pumped onto a preparative scale Whelk-O(S,S) column (2 inch). Details as follows: Column-Whelk-O(S,S) (50×250 mm, 10 micron); Detection-UV DAD-300 nm (bandwidth 180 nm, reference 550 nm (bandwidth 100 nm)); Flow Rate-70 ml/min; Mobile Phase A: Heptane; Mobile Phase B: IPA; Isocratic method (premixed) 5% B; Runtime-60 min; Number of runs-8) to yield the title compound (second eluting peak from the chiral column) as a yellow solid (441 mg). LCMS (Method B): Rt=1.27 min, MH+=414 The following intermediate was obtained as the first eluting peak from the chiral separation above: Intermediate 38: 1,1-dimethylethyl 3-{[(7-chloropyrido[3,4-b]pyrazin-5-yl)amino]methyl}-4,4-difluoro-1-piperidinecarboxylate (Isomer 1) LCMS (Method B): Rt=1.27 min, MH+=414

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Electric Literature of 23611-75-8, These common heterocyclic compound, 23611-75-8, name is Methyl 6-chloropyrazine-2-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 12; 6-((3aR,6aS)-hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)-N-(2-methylbenzyl)pyrazine-2-carboxamide; Example 12A; 6-Chloro-pyrazine-2-carboxylic Acid 2-methyl-benzylamide; The product from Example 1E (1.00 g, 5.79 mmol) and MgCl2 (1.11 g, 11.7 mmol) were suspended in THF (25 mL) and stirred at ambient temperature for 5 min. 2-Methylbenzylamine (1.8 mL, 14.5 mmol) was added, and the reaction was stirred at ambient temperature for 16 h. The reaction mixture was diluted with water (150 mL) and extracted with CH2Cl2 (4×100 mL). The organic extracts were combined and washed with 0.25M HCl (aq) (100 mL) and brine (100 mL), dried over Na2SO4, filtered and concentrated under vacuum. The residue was purified by silica gel chromatography to afford the title compound as a white solid (1.35 g, 89%). 1H NMR (DMSO-d6, 300 MHz) delta ppm 2.33 (s, 3H), 4.48 (d, J=6.10 Hz, 2H), 7.12-7.26 (m, 4H), 9.02 (s, 1H), 9.15 (s, 1H) 9.33 (t, J=5.76, 1H). MS (DCI/NH3) m/z 262 (M+H)+.

The synthetic route of 23611-75-8 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 5900-13-0,Some common heterocyclic compound, 5900-13-0, name is 5-Bromo-3-methoxypyrazin-2-amine, molecular formula is C5H6BrN3O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example B-79: Preparation of 3-{4-[3-(5-Amino-6-methoxy-pyrazin-2-yl)-1-(2,2-difluoro-ethyl)-1H- pyrazol-4-yl]-pyrimidin-2-ylamino}-propionitrilePreparation of B-79-2:To a solution of 5-bromo-3-methoxypyrazin-2-amine (4.50 g, 19.8 mmol) and 4-(dimethylamino)pyridine (1.24g, 10.1 mmol) in 70ml THF was added di-terf-butyldicarbonate (10.4 g, 47.6 mmol) and the reaction mixture was stirred at room temperature for 5.5 hour. The solvents were removed under reduced pressure and the residue was flash chromed on silica gel eluting 3:1 Hexanes/EtOAc to give B-79-2 as a white solid (5.403g, 67%). Example 1-1 : Preparation of (2S)-1-({4-[3-(5-amino-6-methoxypyrazin-2-yl)-1-(2,2-difluoroethyl)-1H- pyrazol-4-yl]pyrimidin-2-yl}amino)propan-2-olPreparation of 1-1-11-1-1 To a solution of 5-bromo-3-methoxypyrazin-2-amine (4.05g, 19.8mmol) in 70 mL dry THF was added DMAP (1.24g, 10,1 mmol) followed by boc anhydride (10.4g, 47.6mmol) in one portion at room temperature. The resulting mixture was allowed to stir at room temperature. When the starting material was gone by TLC, the reaction mixture was concentrated under reduced pressure to an amber oil. A precipitate developed when the oil residue was slurried in 3:1 Hexanes/EtOAc which was collected. The precipitate was dissolved in EtOAc and washed with saturated aqueous NaCI with some 0.5N HCI so pH was -5. The organic layer was dried over MgSO4 and cone. The crude product was purified by silica gel chromatography (eluting 3:1 Hexanes/EtOAc) to give 5.4Og of compound 1-1-1 as a white solid. 1 H NMR (400 MHz, DMSO-d6) delta ppm 1.36 (s, 18 H) 3.99 (s, 3 H) 8.37 (s, 1 H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Bromo-3-methoxypyrazin-2-amine, its application will become more common.

Related Products of 14508-49-7, These common heterocyclic compound, 14508-49-7, name is 2-Chloropyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step A: Preparation of (4-(Pyrazin-2-yl)phenyI)methanol.A mixture of 2-chloropyrazme (0.230 ml, 2.62 mmol), 4-(hydroxymethyl)phenylboronic acid (517 mg, 3.41 mmol), tetrakis(t?phenylphosphine)palladium (0) (303 mg, 0.262 mmol) and 2 M potassium phosphate aqueous solution (2.62 ml, 5.24 mmol) in dioxane (10 mL) was heated at 80 0C overnight under nitrogen. The mixture was cooled down, poured into water and extracted with ethyl acetate. The combined organic layers were dried and concentrated. The residue was purified by preparative HPLC to give the title compound (350 mg) as an off-white solid. LCMS m/z = 187.0 [M+H]+. 1H NMR (400 MHz, CDCl3) delta 4.79 (s, 2H), 7.52 (d, J= 8.1 Hz, 2H), 8.02 (d, J = 8.1 Hz, 2H), 8.51 (d, J= 2.5 Hz, IH), 8.63 (dd, J = 2.4 and 1.6 Hz, IH), 9.03 (d, J= 1.6 Hz, IH).

Statistics shows that 2-Chloropyrazine is playing an increasingly important role. we look forward to future research findings about 14508-49-7.

Related Products of 19847-12-2,Some common heterocyclic compound, 19847-12-2, name is Pyrazinecarbonitrile, molecular formula is C5H3N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A solution of nitrile 3 in ethanol/H2O (0.6 M, 8:1 v/v) was passed through the column reactor R2 (100 mm × 10 mm, 5 g hydrous zirconia) heated at 100 C, with a residence time of 20 minutes, to obtain a quantitative recovery of the primary amide 2 after concentration of the reactor output (>98% yield). White solid; m.p. 191-194 C; delta H (400 MHz, d6-DMSO, 25 C) 7.84 (1H, br. s), 8.24 (1H, br. s), 8.70 (1H, dd, J = 2.5 Hz, J 1.5 Hz), 8.85 (1H, d, J = 2.5 Hz), 9.17 (1H, d, J = 1.5 Hz); delta C (100 MHz, CDCl3, 25 C) 143.46 (CH), 143.69 (CH), 145.18 (C), 147.46 (CH), 165.13 (C); FTIR (neat, nu): 3422, 3132, 1669, 1583, 1525, 1481, 1432, 1373, 1171, 1089, 1046, 1021, 870, 791 cm-1; LC-MS: retention time 0.28 min, m/z [M + H]+ = 124.19; HRMS (ESI): m/z calcd for C5H6ON3+: 124.0505; found 124.0504. Elemental analysis: calcd C = 48.78%, H = 4.09%, N = 34.13%; found C = 48.60%, H = 4.19%, N = 33.70%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Pyrazinecarbonitrile, its application will become more common.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 32111-21-0, name is 2-Iodopyrazine, A new synthetic method of this compound is introduced below., HPLC of Formula: C4H3IN2

To a solution of 3-nitrophenol (0.151 g, 0.733 mmol) in DMSO (5 mL) was added NaH (35 mg of a 60% dispersion, 0.88 mmol) at 0 C under Ar atmosphere. After stirring for 30 min, 2-iodopyrazine (0.133 mg, 0.953 mmol) was added and mixture heated to 85 C for 4h. To the mixture was added satd. NH4Cl solution (25 mL) and the product extracted with EtOAc (2×25 mL). The combined organic extracts were washed with brine, dried (Na2SO4) and concentrated to yield a crude residue which was purified by column chromatography to afford (97 mg, 61% yield) 2-(3-nitrophenoxy)pyrazine as a white solid.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 77112-52-8, name is Ethyl imidazo[1,2-a]pyrazine-2-carboxylate, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of Ethyl imidazo[1,2-a]pyrazine-2-carboxylate

Step 2: 5, 6,7, 8-Tetrahydroimidazo [1,2-a] pyrazine-2-carboxylic acid ethyl ester, Hydrochloride :; 0.46 M HCI-EtOH (169 mL) and 10% Pd-C (50% wet) (1.37 g) were added to the EtOH (546 mL) solution of imidazo [1,2-a] pyrazine-2-carboxylic acid ethyl ester (13.7 g). The mixture was hydrogenated under H2 at 40 psi at room temperature for 15 h. The reaction mixture was filtered and Pd-C was washed with EtOH. The filtrate was concentrated under reduced pressure. The residue was applied to silica gel column chromatography, then the column was eluted with CHCI3-MeOH (9/1- 2/1). The titled compound was obtained as brown crystals Yield : 10.4 g, 63%. ‘H NMR (CDCI3) 8 d 1.38 (t, 3H, J = 7.1 Hz), 3.90 (t, 2H, J = 5.7 Hz), 4.40 (q, 2H, J= 7.1 Hz), 4.59 (t, 2H, J= 5.7 Hz), 4.80 (s, 2H), 8.20 (s, 1H).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 77112-52-8.

Related Products of 345311-03-7, A common heterocyclic compound, 345311-03-7, name is tert-Butyl 5,6-dihydroimidazo[1,2-a]pyrazine-7(8H)-carboxylate, molecular formula is C11H17N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

1,1-Dimethylethyl 5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-7-carboxylate (Description 163, 505 mg, 2.26 mmol) in dichloromethane (2.5 mL) was added to stirred, cooled (0 C.) trifluoroacetic acid (5 mL) and the mixture was stirred at 0 C. for 15 minutes, then at room temperature for 45 minutes. The solvent was evaporated under reduced pressure to give the title compound. m/z (ES+) 124 (M+1).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.