Month: April 2021

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1458-01-1, name is Methyl 3,5-diamino-6-chloropyrazine-2-carboxylate belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below. Formula: C6H7ClN4O2

General procedure: Methyl 3,5-diamino-6-chloropyrazine-2-carboxylate 2 (1 eq.) was combined with K2CO3 (10 eq.), the appropriate (het)aryl boronic acid (1.5 eq.) and Pd(PPh3)4 (5 mol%) in a two-neck round bottom flask. The flask was connected to a condenser and purged with nitrogen. A 4:1 mixture of anhydrous toluene: MeOH (60 mL) was added via syringe and the reaction mixture was heated at reflux for 0.5-18 h. The mixture was allowed to cool to room temperature and filtered through Celite (10 x 3 cm, eluting with 3 x 20 mL EtOAc). The filtrate was evaporated to dryness and the residue purified by silica gel flash column chromatography using EtOAc/pet spirit.

The synthetic route of 1458-01-1 has been constantly updated, and we look forward to future research findings.

Application of 875781-43-4, A common heterocyclic compound, 875781-43-4, name is 2-Bromo-5H-pyrrolo[2,3-b]pyrazine, molecular formula is C6H4BrN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A 10 mL microwave vial was charged with 5-bromo-4,7-diazaindole (0.471 g, CASRN 875781-43-4), 4-pyridylboronic acid (0.58 g), lM Na2C03 (3 mL), l,l ‘-(dppf)Pd(II)Ci2 (0.097 g) and MeCN (3 mL), capped and irradiated in a microwave reactor at 150 C for 30 min. The reaction was cooled and partitioned between H20 and EtOAc. The aqueous layer was twice washed with EtOAc. The combined organic layers were washed once with brine, dried (MgS04), filtered and concentrated to afford a solid residue. The crude purified by Si02 chromatography eluting with an EtOH/EtOAc gradient (1 to 20% EtOH over 12 min) to afford 0.28g of pure 2- (pyridin-4-yl)-5H-pyrrolo[2,3-b]pyrazin (22).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference of 6966-01-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6966-01-4, name is Methyl 3-amino-6-bromopyrazine-2-carboxylate belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.

To a solution of methyl 3-amino-6-bromopyrazine-2-carboxylate (4.6 g, 20.0 mmol) and 4-(2-(benzyloxycarbonylamino)ethyl)phenylboronic acid (6.58 g, 22.0 mmol) in 50 mL of dioxane was added 2M Na2C03 solution (20 ml, 40.0 mmol). The reaction mixture was purged with a nitrogen before the addition of PdCl2(dppf) (1.5 g, 2.0 mmol). The reaction mixture was heated at 90 C for 1.5 h under a balloon of nitrogen. The reaction mixture was cooled and diluted with ethyl acetate and saturated NaHCO-, solution. The organic layer was separated and dried over magnesium sulfate. The filtrate was concentrated and the residue was purified by silica gel chromatography (ISCO; 80g cartridge: ethyl acetate/dichloromethane, 0-50%) to give the title compound as a light yellow solid which was dissolved in 60 mL of EtOH and 10 mL of THF. 30 mL (60 mmol) of 2N LiOH was added and the mixture was stirred at room temperature overnight. The reaction mixture was concentrated then treated with 2N HC1 solution to pH=5 to effect a light yellow precipitate that was filtered and air dried for use without further purification. [M+H]+ = 392.2.

The synthetic route of Methyl 3-amino-6-bromopyrazine-2-carboxylate has been constantly updated, and we look forward to future research findings.

Related Products of 33332-29-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 33332-29-5, name is 2-Amino-5-chloropyrazine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.

17 (1.1 g, 8.5 mmol) was dissolved in dichloromethane (25 mL) followed by the addition of NBS (1.52 g, 8.5 mmol) in batches over a period of 15 min at room temperature. When the reaction was completed, saturated aqueous Na2CO3 solution (10 mL) was added. After stirring for 10 min, the mixture was partitioned between dichloromethane (100 mL) and water (100 mL). The organic layer was dried over anhydrous Na2SO4, decolorized with activated charcoal (0.5 g), and concentrated to give a yellow solid (1.53 g, yield 87%). 2-Amino-3-bromo-5-chloropyrazine (18a) Yield: 87%, yellow solid, M.p.: 108-110 C. 1H NMR(400 MHz, CDCl3): delta 7.97 (s, 1H), 5.08 (s, 2H). 1H NMR(400 MHz, DMSO-d6): delta 8.10 (s, 1H), 6.99 (s, 2H). 13CNMR (125 MHz, CDCl3):delta 151.66, 140.26, 134.75, 123.27. EI-MS m/z: 207 (M+, Cl35, Br79,76), 209 (M+, Cl37,Br79 and Cl35,Br81,100), 211 (M+, Cl37, Br 81,26), 128 (M+,Cl35,-Br, 75), 130 (M+, Cl37,-Br, 25), 101 (M+, Cl35,-Br,-HCN, 30), 103 (M+, Cl37,-Br, -HCN, 10).

The synthetic route of 2-Amino-5-chloropyrazine has been constantly updated, and we look forward to future research findings.

Related Products of 1458-01-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1458-01-1, name is Methyl 3,5-diamino-6-chloropyrazine-2-carboxylate, This compound has unique chemical properties. The synthetic route is as follows.

Preparation 14 3-Chloro-pyrazine-2,6-diamineLithium hydroxide (12.4g, 0.30 mol) was added to a stirred suspension of 3,5-diamino- 6-chloro-pyrazine-2-carboxylic acid methyl ester (20 g, 99 mmol) in methanol (300 ml) and water (120 ml) and the reaction heated at 9O0C for 1.5 hours before allowing to cool to room temperature. The reaction was concentrated in vacuo to afford a yellow slurry and this was suspended in 1 ,4-dioxane (350 ml) and 2M aqueous HCI solution (200 ml,) was added. The mixture was heated at 100 0C for 2 hours and then allowed to cool before removing the 1 ,4-dioxane in vacuo. The resulting aqueous solution was taken to pH 8 using sodium carbonate (saturated aqueous) and extracted into ethyl acetate (3 x 300 ml). The combined organic layers were washed with brine (300 ml), dried (Na2SO4) and concentrated in vacuo to afford a yellow solid (11.7g, 82percent).1HNMR(d6-DMSO): 5.95(br s, 2H), 6.02(br s, 2H), 6.82(s, 1 H).

The chemical industry reduces the impact on the environment during synthesis Methyl 3,5-diamino-6-chloropyrazine-2-carboxylate. I believe this compound will play a more active role in future production and life.

Some common heterocyclic compound, 21279-64-1, name is 5-Chloropyrazine-2-carboxamide, molecular formula is C5H4ClN3O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Formula: C5H4ClN3O

Example 14 (compound No. 234)2,2,2-Trifluoro-1 -(trifluoromethyl)ethyl 4-[2-(5-carbamoylpyrazin-2-ylamino)ethyl]piperidine- 1 -carboxylate14.1 . ie f-Butyl 4-[2-(5-carbamoylpyrazin-2-ylamino)ethyl]piperidine-1 -carboxylate; A mixture of 1.12 g (7.15 mmol) of 5-chloropyrazine-2-carboxamide, 1.95 g (8.58 mmol) of ie f-butyl 4-(2-aminoethyl)piperidine-1 -carboxylate and 1 .18 g (8.58 mmol) of potassium carbonate in 1 .4 ml of dimethyl sulphoxide is heated during 5 hours at 100C under an argon atmosphere and with stirring. After cooling to ambient temperature, 25 ml of ethyl acetate and 25 ml of water are added. The organic phase is separated by settling and washed 3 times with 25 ml of water and then 25 ml of a saturated aqueous sodium chloride solution. It is dried over sodium sulphate and evaporated to dryness. The residue is purified by chromatography on silica gel, elution being carried out with a 97:3, then 95:5 and 93:7 mixture of dichloromethane and methanol, in order to obtain 1 .99 g (5.69 mmol) of product in the form of a light-yellow paste.1H NMR (CDCI3, delta ppm, 200 MHz): 8.65 (s, 1 H), 8.10 (s, 1 H), 7.55 (m, 1 H), 5.75 (m, 1 H), 4.85 (m, 1 H), 4.15 (m, 2H), 3.45 (m, 2H), 2.75 (t, 2H), 1 .80-1 .60 (m, 5H), 1 .50 (s, 9H), 1 .35-1 .10 (m, 2H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 21279-64-1, its application will become more common.

Adding a certain compound to certain chemical reactions, such as: 939412-86-9, name is (3-Chloropyrazin-2-yl)methanamine hydrochloride, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 939412-86-9, Computed Properties of C5H7Cl2N3

3-Oxo-cyclobutanecarboxylic acid (3-chloro-pyrazin-2-ylmethyl)-amide: 3-Oxo-cyclobutanecarboxylic acid 2,5-dioxo-pyrrolidin-1-yl ester (284 mg, 1.35 mmol), C-(3-chloro-pyrazin-2-yl)-methylamine hydrochloride salt (243 mg, 1.35 mmol), and NaHCO3 (298 mg, 3.55 mmol) were dissolved in THF (2.0 mL) and water (2.0 mL) and the reaction was stirred at rt. After 30 min, the layers were allowed to separate and the aqueous layer was removed. The aqueous layer was back extracted with EtOAc. The organics were dried over MgSO4, filtered, and concentrated in vacuo to provide the title compound as a waxy pale yellow solid. 1H NMR (400 MHz, DMSO-d6) delta 3.10-3.27 (m, 5H), 4.56 (d, 2H, J=5.6 Hz), 8.44 (d, 1H, J=3.2 Hz), 8.63 (d, 1H, J=2.4 Hz), 8.73 (t, 1H, J=5.2 Hz).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, (3-Chloropyrazin-2-yl)methanamine hydrochloride, and friends who are interested can also refer to it.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 36070-80-1, name is 5-Chloropyrazine-2-carboxylic acid, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C5H3ClN2O2

[000198] A solution of 5-chloro-pyrazine-2-carboxylic acid (10.00 g, 63.07 mmol) in tetrahydrofuran (126 mL) was treated with a solution of TERT-BUTYL 2,2, 2- trichloroacetimidate (23 ML, 126.14 mmol) in cyclohexane (126 mL). The reaction was stirred at 25C for 5 min and then was treated with boron trifluoride dimethyl etherate (3.2 mL, 25.23 mmol). The resulting reaction mixture was stirred at 25C for 16 h and then was diluted with ethyl acetate (200 mL), washed with a saturated aqueous sodium bicarbonate solution (200 mL) and water (200 mL), dried over sodium sulfate, filtered, and concentrated in vacuo. Biotage chromatography (FLASH 65M, Silica, 10% ethyl acetate/hexanes) afforded 5-chloro-pyrazine-2-carboxylic acid TERT-BUTYL ester (12.73 g, 94%) as a colorless oil: EI-HRMS m/e calcd for C9HNCLN202 (M) 214.0502, found 214.0510.

According to the analysis of related databases, 36070-80-1, the application of this compound in the production field has become more and more popular.

Application of 6863-73-6,Some common heterocyclic compound, 6863-73-6, name is 3-Chloropyrazin-2-amine, molecular formula is C4H4ClN3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Pre Step A 3-(Methyloxy)-2-pyrazinamine A mixture of 3-chloro-2-pyrazinamine (200 mg, 1.544 mmol) and sodium methoxide (250 mg, 4.63 mmol) in methanol (3.9 ml) was heated to 130° C. via a microwave reactor for 60 min. The crude product mixture was purified by RP-HPLC to give 3-(methyloxy)-2-pyrazinamine (113 mg, 0.903 mmol, 59percent yield). MS (ES+) m/z 125.8 (MH+).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Chloropyrazin-2-amine, its application will become more common.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 78605-10-4, name is 6-Phenyl-5H-pyrrolo[2,3-b]pyrazine, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 6-Phenyl-5H-pyrrolo[2,3-b]pyrazine

6-phenyl-5H-pyrrolo[2,3-b]pyrazine (0.8 g) was dissolved in dimethylformamide (40 ml) and sodium hydride (60% dispersion in mineral oil) (246 mg) was added under ice cooling, followed by stirring for 10 minutes. Then, methyl iodide (0.88 g) was added dropwise and the mixture was stirred at room temperature for one day. The reaction solution was mixed with ice water, extracted with ethyl acetate, washed with saturated brine, dried and then concentrated. The residue was purified by silica gel column chromatography (n-hexane:ethyl acetate = 4:1 to 1:1) to obtain the objective product (0.68 g).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 78605-10-4.