Month: April 2021

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 22047-25-2, name is Acetylpyrazine, This compound has unique chemical properties. The synthetic route is as follows., name: Acetylpyrazine

A magnetic stirrer is added to the 250ml single-mouth eggplant bottle.Then add 1.85 g of p-bromobenzaldehyde, 2.44 g of 2-acetylpyrazine and 40 ml of ethanol.After stirring to completely dissolve, add 0.40 g of NaOH and 30 ml of concentrated ammonia water, and stir at room temperature for 6 hours.Filtration under reduced pressure, the filter cake was washed with ethanol and deionized water, and dried in vacuo to give Intermediate 4 as white solid, yield 1.75 g, yield 44.1%.The product was not further purified and the next reaction was carried out directly.

According to the analysis of related databases, 22047-25-2, the application of this compound in the production field has become more and more popular.

Application of 24241-18-7, A common heterocyclic compound, 24241-18-7, name is 2-Amino-3,5-dibromopyrazine, molecular formula is C4H3Br2N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

18b (3.0 g, 12 mmol) was added into acetic acid (20 mL) and concentrated sulfuric acid (4 mL) under ice bath. To this mixture was added a pre-prepared solution of NaNO2 (1.65 g, 24 mmol) in water (10 mL). The reaction mixturewas stirred at room temperature for 3 h, and then poured into ice water (100 g). The precipitate was collected by filtrated, washed with water and dried to give an off-white solid (1.8 g, yield 61%). 3,5-Dibromo-2-hydroxylpyrazine (21b)Yield: 61%, off-white solid, M.p.: 182-184 C. 1H NMR(400 MHz, CDCl3):delta 11.23 (br, 1H), 7.53 (s, 1H). 1HNMR (400 MHz, DMSO-d6): delta 13.16 (s, 1H), 7.94 (s, 1H).13C NMR (125 MHz, CD3OD): delta 154.19, 136.73, 131.57, 114.62. ESI-MS m/z: 250.9 [M – H]-.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 33332-29-5, name is 2-Amino-5-chloropyrazine, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 33332-29-5

General procedure: To a solution of 5-chloropyrazin-2-amine (0.2 g, 1.54 mmol) in MeOH (3 mL) was added Cu powder (0.13 g, 2.07 mmol), followed by a solution of sodium methoxide in MeOH (0.38 mL, 1.75 mmol). The reaction mixture was stirred at 150C in a sealed tube for 24 h. The reaction mixture was then filtered through Celite, and the filtrate was concentrated in vacuo. The crude product obtained was purified by column chromatography (silica: 100-200 mesh, MeOH:DCM 2-3%) to afford the title compound (0.13 g, 67%). LCMS (ES+) 126 (M+H)+, RT 1.06 minutes (method 1).

According to the analysis of related databases, 33332-29-5, the application of this compound in the production field has become more and more popular.

These common heterocyclic compound, 6966-01-4, name is Methyl 3-amino-6-bromopyrazine-2-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 6966-01-4

To 3-aminopyridine (10 g, 106 mmol) at 70 C were added methyl 3-amino-6-bromo-2- pyrazinecarboxylate (1.0 g, 4.3 mmol) and 1, 8-DIAZABICYCLO [5.4. 0] undec-7-ene (645 UL, 4.3 mmol). The reaction solution was stirred for 4 h, diluted with water (75 mL) and extracted with methylene chloride. The combined organic layers were washed with a saturated ammonium chloride solution, dried (MGS04), filtered and evaporated in vacuo. The crude product was purified on a silica gel column using methylene CHLORIDE/ETHANOL, (9: 1), as the eluent to give 750 mg (59% yield) of the title compound as a yellow solid: 1 H NMR (CDC13, 400 MHz) 8 9.50 (br s, 1 H), 8.82 (d, J = 3 Hz, 1 H), 8.43 (dd, J = 5 and 1 Hz, 1 H), 8.31 (s, 1 H), 8.23 (ddd, J = 8,3 and 2 Hz, 1 H), 7.34 (dd, J = 8,5 Hz, 1 H); MS (TSP) M/Z 294 (M++1).

The synthetic route of Methyl 3-amino-6-bromopyrazine-2-carboxylate has been constantly updated, and we look forward to future research findings.

Electric Literature of 41110-29-6, These common heterocyclic compound, 41110-29-6, name is Methyl 3-methylpyrazine-2-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of methyl 3-methylpyrazine-2-carboxylate (9.1 g, 59.8 mmol) in DCM (100 mL) at 0 C., was added urea hydrogen peroxide adduct, 97% (7.81 g, 83 mmol) and trifluoroacetic acid anhydride (10.8 ml, 78 mmol) dropwise. The resulting mixture was stirred at 0 C. for 1 h, and at room temperature for 18 h. The reaction was diluted with DCM and quenched with saturated Na2SO3 solution; the aqueous layer was back-extracted with DCM. The combined organic extracts were dried (MgSO4), filtered and concentrated in vacuo. The crude mixture was purified with ISCO (20% to 80% EtOAc/Hexanes) to afford a mixture of products: 2-(methoxycarbonyl)-3-methylpyrazine 1-oxide (5.2 g, 51.7% yield) and 3-(methoxycarbonyl)-2-methylpyrazine 1-oxide. The mixture was taken to next step without further purification.

The synthetic route of 41110-29-6 has been constantly updated, and we look forward to future research findings.

Some common heterocyclic compound, 1379338-74-5, name is 5,7-Dichloropyrido[3,4-b]pyrazine, molecular formula is C7H3Cl2N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 1379338-74-5

(C) (9/-/-fluoren-9-yl)methyl 5-(7-chloropyrido[4,3-£>]pyrazi n-5- yl)hexahyd ropy rrolo[3,4-£>] pyrrole- 1 (2H)-carboxylate[0129] The mixture of (9/-/-fluoren-9-yl)methyl hexahydropyrrolo[3,4-£>]pyrrole-1 (2/-/)- carboxylate (100 mg, 0.5 mmol) and 5,7-dichloropyrido[4,3-£>]pyrazine (600 mg, 1 .8 mmol) in dioxane was stirred at 0 C for 30 minutes and then at room temperature for 4 hours. The mixture was concentrated, and the residue was purified by chromatography to give the title compound. MS (m/z): 498 (M+H)+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1379338-74-5, its application will become more common.

Synthetic Route of 87486-34-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 87486-34-8, name is 3,5-Dibromo-1-methylpyrazin-2(1H)-one belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.

General procedure: To a solution of 2a-j (10 mmol, 1.0 eq) , 3,5-dibromo-1-methylpyrazin-2(1H)-one (2.95 g, 11 mmol, 1.1 eq) and DIEA (3.3 mL,20 mmol, 2.0 eq) in MeCN (20mL) was stirred at 80 °C for 5 hours. After cooling to room temperature, thesolvent was removed in vacuo, and the residue was purified using silica gelchromatography to give the title compounds, yield 72-85percent.

The synthetic route of 3,5-Dibromo-1-methylpyrazin-2(1H)-one has been constantly updated, and we look forward to future research findings.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 486460-21-3, name is 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below. Application In Synthesis of 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine

2-(2,4-Dichlorophenyl)-3-cyano-4-methylsulfonylethyl-6-methylpyridine(Compound III, 0.53 g, 1.38 mmol), DIPEA (0.53 g, 4.14 mmol)Soluble in 10ml DMF,After heating to 60 C for 2.5 h, add 3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-alpha]pyrazine (0.53 g, 2.76 mmol),The temperature was raised to 90 C and stirred for 5 h. The reaction solution was added to 20 ml of water and extracted with EA (10 ml×2).The organic phases were combined, dried over anhydrous sodium sulfate and suction filtered.Concentrated column (CH2Cl2/MeOH)A pale yellow oil was obtained in 0.47 g, yield 71%.

The synthetic route of 486460-21-3 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 4774-14-5, name is 2,6-Dichloropyrazine, A new synthetic method of this compound is introduced below., name: 2,6-Dichloropyrazine

A mixture of 2,6-diehloro- pyrazine (1.2 g, 13.4 mmol, I eq) and 35 mL acetonitrile was combined in a heavy wall pressure vessel followed by the addition of 40percent dimethyl amine (14.7 mmol, 1.1 eq) and K2CO3 (16.1 mmol, 1.2 eq) and purged with argon. The pressure vessel was capped and and heated at 900 °C for 4hr (monitored by TLC/HPLC). The reaction mixture was then cooled to ambient temperature, transferred to a round bottom flask and concentrated in vacuo. The residue was treated with 20 mL of Milli-Q water and the aqueous layer was extracted several times with dichloromethane using a separatory funnel. The combined organic layers were dried with anhydrous sodium sulfate and concentrated in vacuo. The product 2 was purified by column chromatography on silica gel (200-400 mesh) using ethyl acetate: hexane (1 : 1 v/v) eluent. Product 11-2 was obtained as white solid (1.1 g) in 60percent (gravimetric) yield, with an apparent HPLC (tr/purity): 1 8.4 mm, > 90percent (HPLC method A); (EST) m/z (MeOH): 158.10 (MH?).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Synthetic Route of 14508-49-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 14508-49-7, name is 2-Chloropyrazine, This compound has unique chemical properties. The synthetic route is as follows.

Step 1: 2-hydrazinylpyrazine [0204] 2-Chloropyrazine (2.0 g, 17.5 mmol) was added dropwise to a 35% aqueous solution of hydrazine hydrate (25.8 g, 97.8 mmol) at 63-65 C, the addition rate was carefully monitored to ensure that the reaction temperature did not exceed 65 C. Following the addition, the mixture was heated to 65 C. After stirring overnight, the reaction was cooled to room temperature. The solvent was evaporated to afford the title compound as a yellow powder (1.5 g, 75%). MS (ESI) calcd for C4H6N4: 110.1; found: 111.4 [M+H]. *H NMR (400 MHz, CD3OD) delta 8.10 (d, J = 1.6 Hz, 1H), 8.00 (dd, J = 3.2, 1.6 Hz, 1H), 7.73(d, J = 3.2 Hz, 1H).

The chemical industry reduces the impact on the environment during synthesis 2-Chloropyrazine. I believe this compound will play a more active role in future production and life.