Month: April 2021

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 21279-64-1, name is 5-Chloropyrazine-2-carboxamide, A new synthetic method of this compound is introduced below., HPLC of Formula: C5H4ClN3O

General procedure: 150 mg (0.952 mmol) of 5-Cl-PZA (1) or 6-Cl-PZA (2) was dissolved in ethanol together with triethylamine (1 eq., 96 mg, 0.952 mmol). Three equivalents of corresponding alkylamine were added to the reaction mixture and refluxed in ethanol generally for 6 hours. The completion of the reaction was checked by TLC chromatography (eluent: hexane/ethyl acetate, 1:2). The crude product was absorbed on silica by solvent evaporation and purified by flash chromatography (hexane/ethyl acetate gradient elution).

The synthetic route of 21279-64-1 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 61655-77-4, These common heterocyclic compound, 61655-77-4, name is 2-Chloro-6-(4-methylpiperazin-1-yl)pyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Reaction Scheme 12EXAMPLE 43 : 1 -(4-methoxybenzyl)-3 -methyl-5 -(6-(4-methylpiperazin- 1 -yl)pyrazin-2- yP- 1 H-pyrazolo [3 ,4-b”|pyridineTo a stirred solution of 8 and 63 in 1,4 dioxane and water was added CS2CO3, the solution degassed, purged with nitrogen for 15 min, Pd(PPh3)4 was added and the reaction mass was again purged with nitrogen for another 15 min. The reaction mass was heated at 100C in a sealed tube overnight. After completion of the reaction the reaction mass was partitioned between ethyl acetate and water and the organic layer was separated and again extracted with ethyl acetate. The combined organic layer was dried over sodium sulphate and the solvent completely distilled off to get the crude. The crude was passed through 100-200 mesh silica gel eluting the pure compound at 70-80% ethyl acetate in hexane as off white coloured solid compound 64 (25 mg).

The synthetic route of 61655-77-4 has been constantly updated, and we look forward to future research findings.

Application of 33332-29-5, These common heterocyclic compound, 33332-29-5, name is 2-Amino-5-chloropyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of 5-chloropyrazin-2-amine (500 mg, 3.86 mmol) in DCM (5mL) was added NBS (686.92 mg, 3.86 mmol), and the brown mixture was stirred at 40 C for 1 hour. After cooling to r.t., the mixture was filtered through silica gel and eluted with EtOAc (20 mL x 3), and the filtrate was concentrated to give the crude product. The crude product was purified by flash chromatography on silica gel (EtOAc in PE = 20% to 40% to 50%) to give the product (600 mg) as a solid. *H NMR (400MHz, CDC13 ) _ = 7.98 (s, 1H), 5.05 (br s, 2H).

Statistics shows that 2-Amino-5-chloropyrazine is playing an increasingly important role. we look forward to future research findings about 33332-29-5.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 486424-37-7, name is 3-Amino-6-bromopyrazine-2-carboxylic acid belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below. COA of Formula: C5H4BrN3O2

Block B can be prepared according to scheme 2 in FIG. 2. Referring to FIG. 2, the synthesis of Block B can be performed as described below. (0164) Intermediate 6 Block B [0029] To a solution of Intermediate 6 (6.0 g, 27.4 mmol) in DMSO (30 mL) was added CDI (8.9 g, 54.8 mmol), DIPEA (3.8 g, 30.1 mmol) and DMAP (0.17 g, 1.37 mmol). The solution was stirred at rt for 4 hours. Aniline (2.5 g, 27.4 mmol) was added and the mixture was stirred at rt overnight. Water was added and the formed solid was collected by filtration. The crude product was purified by silica-gel column to afford 2.5 g of Block B (31 %) as yellow solid. (0165) [0030] LC-MS (M+l): 293.2; 1H MR (400 MHz, DMSO-d6) 510.28 (s, 1H), 8.42 (s, 1H), 7.78 (d, J = 8.0 Hz, 2H), 7.74 (s, 2H), 7.36 (t, J = 8.0 Hz, 2H), 7.13 (t, J = 7.6 Hz, 1H) .

The synthetic route of 486424-37-7 has been constantly updated, and we look forward to future research findings.

Related Products of 54608-52-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 54608-52-5, name is 2-Hydrazinopyrazine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.

To a solution of 2-hydrazinylpyrazine (3.00 g, 27.2 mmol) in ethanol (30 mL) was added 3-methylbutanoic anhydride (7.61 g, 40.9 mmol) at 0 , and the resulting mixture was stirred for 1 h at 0 . The reaction solution was then quenched b the addition of water (100 mL), and the resulting mixture was extracted with EtOAc (3 x 100 mL). The combined organic layers were washed with brine (100 mL), dried over anhydrous Na 2 SO4, and filtered The filtrate was concentratedunder reduced pressure to afford 3-methyl-N ‘-. (pyrazin-2-yl) butanehydrazide, which was used in the next step without further purification. MS (ESI) calc’d for (C9 H15 N4 O) [m + H] + 195; found 195

The synthetic route of 2-Hydrazinopyrazine has been constantly updated, and we look forward to future research findings.

Synthetic Route of 59489-71-3, These common heterocyclic compound, 59489-71-3, name is 2-Amino-5-bromopyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

C. 5-(4-(Triisopropylsilyloxy)phenyl)pyrazin-2-amine. Triisopropyl(4-(4,4,5, 5-tetramethyl-l,3,2-dioxaborolan-2-yl)phenoxy)silane (1.1 g, 2.9 mmol), 5- bromopyrazin-2-amine (507 mg, 2.9 mmol), dichloro[l,l’- EPO bis(diphenylphosphino)ferrocene]palladium(II) dichloromethane adduct (64 mg, 0.087 mmol), IM sodium carbonate (8.7 mL, 8.7 mmol), and dioxane (10 mL) were heated in a Biotage Emrys Optimizer microwave reactor at 120 C for 10 min. The reaction was extracted with water and ethyl acetate. The organic layer was dried over magnesium sulfate, filtered and concentrated. The resulting residue was purified using Biotage silica gel chromatography (0-100% ethyl acetate in hexanes) to give a tan solid (0.8 g, 80 % yield). 1H NMR (400 MHz, DMSCW6) delta 8.42 (s, IH), 7.92 (s, IH), 7.80 (d, J=8.6, 2H), 6.90 (d, J=8.6, 2H), 6.45 (s, 2H), 1.26 (q, J=IA, 7.2, 3H), 1.08 (d, J=7.4, 18H); MS (ESI) m/z 344.4 – [M+l]+.

Statistics shows that 2-Amino-5-bromopyrazine is playing an increasingly important role. we look forward to future research findings about 59489-71-3.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 109838-85-9 as follows. Computed Properties of C9H16N2O2

R24 (212 g, 1151 mmol) in tetrahydrofuran (dry) (600 mL) is cooled to ?78° C. Then n-butyllithium (2.5 M in hexanes, 552 mL, 1381 mmol) is added dropwise, keeping the temperature below ?78° C. After 30 min R25 (324 g, 1209 mmol) in tertahydrofurane (dry) (120 mL) is added dropwise. The reaction mixture is stirred at ?78° C. for 1 h. The mixture is quenched with saturated NH4Cl solution and extracted three times with ethyl acetate. The organic layer is washed with brine, dried over Na2SO4 and evaporated in vacuo. The residue is purified by flash chromatography (heptane/ethyl acetate=80/20). Yield 60percent.

According to the analysis of related databases, 109838-85-9, the application of this compound in the production field has become more and more popular.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 59303-10-5 as follows. Computed Properties of C5H5ClN2

Example 38(S)-5-(1 -Methanesulfonyl-1 ,2,3,6-tetrahvdro-pyridin-4-yl)-2-methyl-2-ri -(5- trifluoromethyl-pyrazin-2-yl)-piperidin-4-yl1-2,3-dihvdro-furo[2,3-clpyridineThe title compound is prepared from (S)-5-(1 -methanesulfonyl-1 ,2,3,6-tetrahydro- pyridin-4-yl)-2-methyl-2-piperidin-4-yl-2,3-dihydro-furo[2,3-c]pyridine (Intermediate 41 ; the configuration of the stereocenter is arbitrarily assigned) and 2-chloro-5- (trifluoromethyl)pyrazine in dimethylsulfoxide at 100C in the presence of potassium carbonate. LC (method 4): tR = 1 .06 min; Mass spectrum (EST): m/z = 524 [M+H]+.

According to the analysis of related databases, 59303-10-5, the application of this compound in the production field has become more and more popular.

Application of 5049-61-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 5049-61-6 name is Pyrazin-2-amine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Description 64: 5-bromo-2-pyrazinamine (D64); In a 2 L, ice-bath cooled (NaCl) round-bottomed flask, 2-pyrazinamine (30 g, 315 mmol) was dissolved in DCM (850 ml) NBS (59.0 g, 331 mmol) was added and the reaction mixture was left stirring at 0 0C for 1 hour. The mixture was let to warm-up to room temperature and was left stirring for 1 hour. Solvent was evaporated and the crude was purified by Silica Pad eluting with DCM 100% to DCM/MeOH 90:10. The recovered product was triturated with cyclohexane. The resulting pale yellow solid was filtered through a gouch funnel and dried under vacuum to give the title compound D64 (23.6 g). Mother liquors were concentrated under vacuum to give a second batch of title compound D64 (4.8 g). Impure fractions coming from the silica pad were purified by Silica Chromatography (Biotage SP – column size 34Og) using DCM 100% to DCM/MeOH 90 : 10 as eluent. It was recovered a third batch of title compound D64 (7.2 g). UPLC (Acid Final QC): rt = 0.54 minutes, peak observed: 174 (M) C4H4BrN3 requires 174. 1H NMR (400 MHz, DMSO-J6) delta ppm 6.64 (br. s., 2 H) 7.70 (d, 1 H) 8.04 (d, 1 H)

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Pyrazin-2-amine, and friends who are interested can also refer to it.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 14508-49-7, name is 2-Chloropyrazine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below. Computed Properties of C4H3ClN2

Using Procedure AU-3 (Table 5) with 2-chloropyrazine the title compound 476 was obtained (4.4 g, 46%) as a yellow solid. MS (m/z): 111.0 (M+H)

The synthetic route of 14508-49-7 has been constantly updated, and we look forward to future research findings.