Month: April 2021

69214-33-1, name is 8-Chloroimidazo[1,2-a]pyrazine, belongs to pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. name: 8-Chloroimidazo[1,2-a]pyrazine

Example 2 – Synthesis of A/-(3-(8-(3-fluorophenylamino)imidazori,2-a1pyrazin-3- vDphenvDacetamide (Compound 160)3-Bromo-8-chloroimidazo[ 1 ,2-a”|pyrazine[00239] Bromine (1.42 mL, 27.72 mmol) was added to a suspension of 8- chloroimidazo[l,2-a]pyrazine (2.83 g; 18.48 mmol) in glacial acetic acid (55 mL) and the resulting mixture was stirred at room temperature for 16 hours. The reaction mixture was then concentrated in vacuo and the resulting residue was taken up in DCM/methanol (9:1), subsequently washed with saturated aqueous sodium bicarbonate solution (2 x 70 mL), IM sodium thiosulfate (70 mL), brine (70 mL), dried (MgSO4) and concentrated in vacuo to give the title compound (3.397 g, 79%) as a light brown/golden solid. 1H NMR (d6-DMSO): 8.49(IH, d, J4.6), 8.04 (IH, s), 7.89-7.84 (IH, br m).[00240] The use of Br2/acetic acid could give partial bromination, along with partial chloride displacement by bromide, giving a mixture of 4 possible products A:B:C:D in a1 :2: 1 : 1 mixture. The dihalo species C and D were separated from the monohalo analogues A and B so the final compound was a mixture of two dihaloimidazopyrazines. This product composition could alter on a larger scale.X = Cl, A X = Cl, CX = Br, B X = Br, DA:B:C:D = 1 :2:1 :1

The synthetic route of 69214-33-1 has been constantly updated, and we look forward to future research findings.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 30818-40-7 as follows. Safety of 3,5,6-Trichloropyrazine-2-carbonitrile

101881 To a solution of 3,5,6-trichloropyrazine-2-carbonitrile (5 g, 23.99 mmol) in dioxane (20 mL) at 0 C under nitrogen was added propan-2-amine (4.09 mL, 48.0 mmol). The reaction solution was stirred at 23 oC for 4 h, then quenched with brine (300 mL) and extracted with ethyl acetate (2 x 200 mL). The organic layers were combined, dried over anhydrous MgSO4, filtered and concentrated. The residue was purified via flash column chromatography (5-30% EtOAc in heptane) to afford the title compound (5 g, 90%). 1H NMR (500 MHz, DMSO-d6) oe ppm 1.23 (d, J=6.83 Hz, 6 H) 4.22 (dt, J=8.05, 6.47 Hz, 1 H) 8.27 (d, J=7.81 Hz, 1 H); ESI-MS mlz [M+H]+ 231.0.

According to the analysis of related databases, 30818-40-7, the application of this compound in the production field has become more and more popular.

These common heterocyclic compound, 88625-24-5, name is 5-Chloropyrazine-2-carbaldehyde, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C5H3ClN2O

To a solution of 5-chloropyrazine-2-carbaldehyde (500 mg, 3.51 mmol) in CH2Cl2 (10 mL) was added (diethylamino)difluorosulfonium tetrafluoroborate (2.0 g, 8.77 mmol) and triethylamine trihydrofluoride (0.57 mL, 3.51 mmol). The reaction mixture was stirred for 18 hours at ambient temperature. The reaction mixture was diluted with water and was extracted with CH2Cl2. The organic layer was dried over anhydrous MgSO4, filtered and concentrated under reduced pressure. Purification of the residue via column chromatography (SiO2, heptane:ethyl acetate 0~65%) gave the title (200 mg, 1.22 mmol, 35% yield). 1H NMR (500 MHz, DMSO-d6) delta ppm 9.00 – 8.93 (m, 1H), 8.86 (q, J = 1.1 Hz, 1H), 7.17 (t, J = 54.0 Hz, 1H); MS (ESI+) m/z 186 (M+Na)+.

The synthetic route of 5-Chloropyrazine-2-carbaldehyde has been constantly updated, and we look forward to future research findings.

Application of 109-08-0, A common heterocyclic compound, 109-08-0, name is 2-Methylpyrazine, molecular formula is C5H6N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In the glove box,Mn(CO)5Br (0.005 mmol),[(E)-2-(2-(1-(2-pyridyl)ethylidene)-indenyl)pyridine] (0.006 mmol),Add 1.0 mL of toluene,After stirring for two hours,Add 2-methylpyrazine 1a (2mmol),Benzyl alcohol 2a (1mmol),After the reaction at 135 C for 48 hours, the reaction was stopped.Evaporate the solvent,Column chromatography ethyl acetate / petroleum ether (1:10),Trans-disubstituted olefin derivative 3a.The product is a white solid.The yield was 81%.

The synthetic route of 109-08-0 has been constantly updated, and we look forward to future research findings.

Reference of 36070-80-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 36070-80-1, name is 5-Chloropyrazine-2-carboxylic acid belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.

A resealable reaction vial was charged with 5-chloropyrazine-2-carboxylic acid (500 mg, 3.15 mmol) and sulfurooyl dichloride (5.73 mL, 78.7 mmol). The mixture was charged with DMF (3 drops) and heated to 80 C for 3.5 h. The solvent was removed in vacuo and chased with toluene to give a yellow crystalline solid.

The synthetic route of 5-Chloropyrazine-2-carboxylic acid has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 36070-80-1, name is 5-Chloropyrazine-2-carboxylic acid, A new synthetic method of this compound is introduced below., SDS of cas: 36070-80-1

5-Hydroxypyrazine-2-carboxylic acid [CAS RN: 34604-60-9] (500 mg, 3.57 mmol,1.0 eq) was treated with thionyl chloride (3.90 mL, 53.5 mmol, 15 eq) and 0.04 mL DMF. Then, the reaction mixture was heated to reflux temperature for 4 h. On cooling, the volatile components were removed in vacuo. The crude material remaining was diluted with toluene and the resulting solution was concentrated by the use of a rotary evaporator. This procedure was repeated two more times.Then, the remaining material was treated with 4 mL DMF and with 2-methoxy-N- methylethanamine [CAS-RN: 38256-93-8] (795 mg, 8.92 mmol, 2.5 eq). The reaction mixture was stirred at rt overnight. The volatile components were removed in vacuo and the crude material was purified via preparative MPLC (Biotage Isolera; 25 g SNAP cartridge: hexane -> hexane/ethyl acetate 2/1 ->ethyl acetate ) to give 290 mg (34% yield of theory) of the title compound.UPLC-MS (Method 1): R = 0.76 mm; MS (EI0): m/z = 230 [M+H].

The synthetic route of 36070-80-1 has been constantly updated, and we look forward to future research findings.

Application of 55557-52-3, These common heterocyclic compound, 55557-52-3, name is 3-Chloropyrazine-2-carbonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

(a). (3-Chloropyrazin-2-yl)methanamine hydrochloride was prepared as follows. To a solution of 3-chloropyrazine-2-carbonitrile (160 g, 1 .147 mol) in acetic acid (1.5 L) was added Raney Nickel (50% slurry in water, 70 g, 409 mmol). The resulting mixture was stirred under 4 bar hydrogen at room temperature overnight. Raney Nickel was removed by filtration over decalite and the filtrate was concentrated under reduced pressure and co-evaporated with toluene. The remaining brown solid was dissolved in ethyl acetate at 50C and cooled on an ice-bath. 2M hydrogen chloride solution in diethyl ether (1 .14 L) was added in 30 min. The mixture was allowed to stir at room temperature over weekend. The crystals were collected by filtration, washed with diethyl ether and dried under reduced pressure at 40C. The product brown solid obtained was dissolved in methanol at 60C. The mixture was filtered and partially concentrated, cooled to room temperature and diethyl ether (1000 ml) was added. The mixture was allowed to stir at room temperature overnight. The solids formed were collected by filtration, washed with diethyl ether and dried under reduced pressure at 40C to give 153.5 g of (3-chloropyrazin-2- yl)methanamine.hydrochloride as a brown solid (74.4 %, content 77 %).

The synthetic route of 55557-52-3 has been constantly updated, and we look forward to future research findings.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 944709-42-6 as follows. Recommanded Product: 944709-42-6

Into a flask under an. inert atmosphere of N2, were placed 6,8-dibromo-[1,2,4]triazolo[1,5-a]pyrazine (6.0 g, 21.6mmol) and bis(triphenylphosphine)palladium(II) dichloride (1.5 g, 2.2 mmol). To this was added the zinc reagent from Step A, and the mixture was stirred at RT for 16 h. The mixture was quenched by the addition of sat. aq. NH4C1 (200 mL), and extracted with EtOAc (3 x 100 mL). The combined organic layer was dried over anhydr. Na2SO4, filtered and the filtrate was concentrated in vacuo to dryness. The residue was purified by column chromatography withEtOAc/petroleum ether (1/5) to afford the title compound.

According to the analysis of related databases, 944709-42-6, the application of this compound in the production field has become more and more popular.

Adding a certain compound to certain chemical reactions, such as: 22047-25-2, name is Acetylpyrazine, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 22047-25-2, HPLC of Formula: C6H6N2O

General procedure: A 100 mL round-bottom flask charged with 2-acetylpyrazine (1.47 g, 2 mmol) was added MeOH (30 mL), KOH pellets (0.675 g,2 mmol) and water (2 mL). The resulting mixture was stirred for10 min and then added corresponding n,n?-dimethoxybenzaldehydes (1.0 g, 1 mmol) and ammonium solution (6 mL) was added slowly stirring at room temperature for 4 h, a white precipitate obtained was filtered, washed with MeOH and diethyl ether. The crude products on recrystallization in a mixture of CHCl3:MeOH (1:1) gave white crystals of desired compounds, 1-4.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Acetylpyrazine, other downstream synthetic routes, hurry up and to see.

Related Products of 951626-95-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 951626-95-2, name is Ethyl 4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxylate belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.

General procedure: To the stirring solution of compound 6a (45 mg,0.18 mmol) in THF (5 mL) was added sodium hydride (9 mg, 0.21 mmol) in portions at 0C and allowed to stir at room temperature for 15 minutes. Reaction mixture was again re-cooled to 0C and thereto was added 3,4-dichlorobenzyl chloride (56 mg,0.22 mmol drop wise and reaction mixture was allowed to stir at room temperature for 15 h. Reaction mixture was poured in ice-chilled water (50 mL) and extracted with ethyl acetate (2 x 50 mL). The combined organic layer was washed with water (40 mL) followed by brine (10 mL), dried over anhydrous sodium sulphate, filtered and the filtrate was evaporated to dryness. The purification using flash column chromatography on silica gel (100-200 mesh) using MeOH in DCM afforded off white colored solid compound 1(65 mg, 89%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxylate, other downstream synthetic routes, hurry up and to see.