Month: April 2021

Reference of 233278-56-3, The chemical industry reduces the impact on the environment during synthesis 233278-56-3, name is 5,6,7,8-Tetrahydro[1,2,4]triazolo[1,5-a]pyrazine, I believe this compound will play a more active role in future production and life.

Description 35: 3-(5,6-Dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-ylmethyl)-2-phenylquinoline-4-carboxylic Acid A mixture of 3-(bromomethyl)-2-phenylquinoline-4-carboxylic acid (Description 5, 3.4 g, 10.3 mmol), 5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyrazine (1.24 g, 9.1 mmol) and triethylamine (1.39 mL, 1.01 g, 10 mmol) in DMF (50 mL) was heated at 60 C. for 40 h. The mixture was cooled and the solvent was evaporated under reduced pressure. EtOAc (500 mL) was added and the mixture was heated to reflux, filtered and cooled. The solvent was evaporated under reduced pressure to a volume of 100 mL and the solid was collected and dried in vacuo to give the title compound as a solid (1.0 g, 28%). m/z (ES+) 386 [M+H+].

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5,6,7,8-Tetrahydro[1,2,4]triazolo[1,5-a]pyrazine, other downstream synthetic routes, hurry up and to see.

Electric Literature of 109838-85-9, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 109838-85-9 as follows.

To a mixture of scheme 5-8 compound S3 (22 g, 0.10 mol) and PPh3 (82.3 g, 0.31 mol) in dry dichloromethane (200 mL) was added perbromomethane (86.95 g, 0.26 mol) in dry dichloromethane (50 mL) dropwise at 0 oC. The reaction was stirred at room temperature overnight and concentrated under reduced pressure to give a residue that was purified by silica gel chromatography (petroleum ether: ethyl acetate=80:1) to afford the title compound (23 g, 66.7% yield) as a yellow oil.

According to the analysis of related databases, 109838-85-9, the application of this compound in the production field has become more and more popular.

Adding a certain compound to certain chemical reactions, such as: 681249-57-0, name is 2-(Trifluoromethyl)-5,6,7,8-tetrahydro[1,2,4]triazolo[1,5-a]pyrazine, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 681249-57-0, Product Details of 681249-57-0

A suspension of Rac-BINAP-Pd-G3 precatalyst (46.5 mg, 0.047 mmol), 2- (trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyrazine (90 mg, 0.469 mmol), (R)- tert-butyl 3-(4-bromo-2-(N,N-dibenzylsulfamoyl)-3-(2-(4-methoxybenzyl)-2H-tetrazol-5- yl)phenylsulfonamido)pyrrolidine-1-carboxylate (REFERENCE EXAMPLE 9) (200 mg, 0.235 mmol) and Cs2CO3 (229 mg, 0.704 mmol) in DME (4 mL) was degassed for 20 min. The reaction mixture was heated to 80 C for over night. The reaction mixture was cooled down to rt, then was chromatographed over silica gel (0-10% MeOH in DCM as eluent) to give the title product. LCMS [M+H]+ 964.2.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(Trifluoromethyl)-5,6,7,8-tetrahydro[1,2,4]triazolo[1,5-a]pyrazine, other downstream synthetic routes, hurry up and to see.

Synthetic Route of 113305-94-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 113305-94-5, name is 5-Aminopyrazine-2-carbonitrile belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.

A solution of (R)-tert-butyl 2-((2-chloro-5-(4-methoxyphenyl)pyridin-4- ylamino)methyl)morpholine-4-carboxylate (0.036 g, 0.083 mmol), 2-amino-4- cyanopyrazine (0.014 g, 0.116 mmol), Xantphos (0.008 g, 0.013 mmol), cesium carbonate (0.054 g, 0.166 mmol), tris(dibenzylideneacetone)dipalladium chloroform complex (0.007 g, 0.008 mmol) in dioxane (0.7 ml_) was stirred at room temperature under nitrogen for 10 min, then heated under microwave irradiation for 60 min at 150 0C. The reaction mixture was purified by ion exchange on SCX-II acidic resin (1 g), eluting with methanol / dichloromethane (1 / 1) then 2M ammonia-methanol. The basic fractions were combined and solvent was removed in vacuo. The crude product was purified by preparative thin layer chromatography, eluting with ethyl acetate / hexane (1 / 1), to give the title compound as a yellow solid (0.014 g, 32%).1H NMR (CDCI3, 500 MHz) delta 8.82 (s, 1H), 8.46 (s, 1H), 7.79 (s, 1H), 7.31 (d, 2H, J = 8.7 Hz), 7.06 (s, 1 H), 7.03 (d, 2H, J = 8.7 Hz), 5.01 (t, 1 H, J = 5.3 Hz), 3.85 (s, 3H), 3.86-3.84 (m, 1H), 3.74-3.64 (m, 1H), 3.30-3.50 (m, 1H), 3.26-3.17 (m, 2H), 2.99 (d, 1 H, J = 13.7 Hz), 2. 86 (2H, d, J = 6.9 Hz), 2.73-2.63 (m, 1 H). LCMS (4) Rt = 2.17 min; m/z (ESI+) 518 [MH+].

The synthetic route of 5-Aminopyrazine-2-carbonitrile has been constantly updated, and we look forward to future research findings.

Synthetic Route of 4744-50-7,Some common heterocyclic compound, 4744-50-7, name is 2,3-Pyrazinecarboxylic anhydride, molecular formula is C6H2N2O3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Pyrazine-2,3-dicarboxylic anhydride (1.0 g, 6.7 mmol) was dissolved in tetrahydrofuran (40 mL)in an Erlenmeyer flask and the corresponding substituted aniline (6.7 mmol, 1 equiv.) was added in one dose. The reaction mixture was stirred for 1 hour at laboratory temperature. Water (30 mL) was added into the mixture followed by the saturated aqueous solution of NaHCO3 until pH 6 to form thecorresponding 3-(phenylcarbamoyl)pyrazine-2-carboxylic acid 1-18. Obtained crystals were filtered off and washed with water. The progress of the procedure was monitored by TLC eluted with thesystem water/butanol/acetic acid 5:4:1.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2,3-Pyrazinecarboxylic anhydride, its application will become more common.

Related Products of 5780-66-5,Some common heterocyclic compound, 5780-66-5, name is Pyrazine-2-carbaldehyde, molecular formula is C5H4N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of pyrazine-2-carboxaldehyde (1.1 g, 10 mMol), sulphur powder (0.6 g, 18 mMol), and piperidine (3 mL) was stirred at 110° C for 2 hrs. The resultant dark brown mixture was left to stand overnight and then was poured into cold water. The solid was collected by filtration and purified by column chromatography (silica gel, dichloromethane) to give 400 mg of crude thio piperidyl amide as a yellow solid. This was dissolved in methanol (5 mL) and hydrazine hydrate (0.1 mL) was added to the solution. The mixture was stirred at room temperature for 1 hr. More hydrazine hydrate (0.5 mL) was added and the mixture was stirred for 1 hr more. After neutralisation with glacial acetic acid the mixture was extracted with ethyl acetate and dried over MgS04. Isatin (300 mg) and glacial acetic acid (1 mL) were added to the solution and the reaction mixture was heated under reflux overnight. The solvent was evaporated in vacuo and the residue was recrystallised from acetonitrile to give the desired product (130 mg) as a beige solid.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Pyrazine-2-carbaldehyde, its application will become more common.

Related Products of 19847-12-2,Some common heterocyclic compound, 19847-12-2, name is Pyrazinecarbonitrile, molecular formula is C5H3N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In a 250 mL round-bottomed flask, pyrazine-2-carbonitrile (10 g, 95.1 mmol), pyridine (2.26 g, 2.33 ml, 28.5 mmol,) and 2-mercaptopropionic acid (10.1 g, 95.1 mmol) were combined to give a light yellow solution. The reaction mixture was heated to 100 C. and stirred for 2 h. Upon cooling, the thick yellow mixture was diluted with 100 mL ethanol and stirred for 30 min. The slurry was then filtered, and washed with diethyl ether (2*100 mL) to give 5-methyl-2-pyrazin-2-yl-thiazol-4-ol (17.86 g, 97.1%) as yellow solid which was used directly without further purification.

The synthetic route of 19847-12-2 has been constantly updated, and we look forward to future research findings.

1458-01-1, name is Methyl 3,5-diamino-6-chloropyrazine-2-carboxylate, belongs to pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: Methyl 3,5-diamino-6-chloropyrazine-2-carboxylate

Step 1 A stirred suspension of 3,5-diamino-6-chloro-pyrazine-2-carboxylic acid methyl ester (110 g, 542.9 mmol) in MeOH (500 ml) at 5-10° C. (ice-bath) is treated dropwise with a suspension of lithium hydroxide (46.6 g, 1111 mmol) in water (500 ml). The reaction mixture is heated to 50° C. for 5 hours then cooled to room temperature and stirred overnight. The resulting precipitate is collected by filtration and dried in a vacuum oven to afford Lithium 3,5-diamino-6-chloro-pyrazine-2-carboxylic acid as the lithium salt (di-hydrate); [M-Li]- 187

The synthetic route of 1458-01-1 has been constantly updated, and we look forward to future research findings.

Application of 33332-28-4, A common heterocyclic compound, 33332-28-4, name is 2-Amino-6-chloropyrazine, molecular formula is C4H4ClN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

6-(3-Fluorophenyl)pyrazin-2-amine To a stirred solution of 2-amino-6-chloropyrazine (2.0 g, 15.43 mmol) in a mixture of toluene (90 ml.) and ethanol (8.5 ml_) was added 3-fluorophenyl boronic acid (2.60 g, 18.51 mmol) and a 2M aqueous solution of sodium carbonate (16.2 mL, 32.40 mmol). The mixture was subjected to three cycles of evacuation-backfilling with argon, and tetrakis(triphenylphosphine)palladium (0.713 g, 0.617 mmol) was added. The mixture was subjected again to three cycles of evacuation-backfilling with argon the flask was capped and placed in a 11O0C oil bath. After 4h, the mixture was cooled, partitioned between dichloromethane and water the organic layer was washed with brine, dried (MgSO4) and evaporated. The residue was purified by silica gel flash chromatography (33percent ethyl acetate in hexanes to 50percent ethyl acetate in hexanes). Concentration in vaccuo of the product-rich fractions provided the titled compound (2.79 g, 95percent) as a yellowish solid (2.79 g, 95percent). delta 1H-NMR (CDCI3): 8.38 (s, 1 H), 7.95 (s, 1H), 7.60 (m, 2H), 7.40 (m, 1 H), 4.65 (s, 2H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Synthetic Route of 143591-61-1, A common heterocyclic compound, 143591-61-1, name is 3-Bromo-8-chloroimidazo[1,2-a]pyrazine, molecular formula is C6H3BrClN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

This solid was suspended in 1 : 1 dichloromethane/methanol (150 ml) and treated with solid sodium methoxide (9.8 g, 0.18 mol). The resulting mixture was then stirred at 40C for 2 h. The reaction was cooled, diluted with water (750 ml) then extracted with dichloromethane (600 ml). The organics were dried over anhydrous magnesium sulphate, filtered and concentrated to give 3-BROMO-8- METHOXYIMIDAZO [L, 2-A] PYRAZINE as a white solid (24.5 g, 89% over 2 steps):

The synthetic route of 143591-61-1 has been constantly updated, and we look forward to future research findings.