Adding a certain compound to certain chemical reactions, such as: 63286-28-2, name is 2-Chloro-3-hydrazinylpyrazine, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 63286-28-2, name: 2-Chloro-3-hydrazinylpyrazine
To a solution of commercial available 2-chloro-3-hydrazinylpyrazine (28 g, 0.19 mol) in dichloromethane (200 mL) was added butyraldehyde (14.7 g, 0.20 mol) and the reaction was stirred at 50 C for 2 hours before cooling to 0 C. Diacetoxyiodobenzene (71 .8 g, 0.223 mol) was added at 0 C. Cooling was removed and the mixture was stirred at 20C for 2 hours. A saturated aq. solution of Na2CO3 (80ml_) was slowly poured into the reaction and the mixture was stirred for 10 minutes. The organic phase was separated, washed with brine (3^50 mL), dried over Na2SO4 and concentrated under vacuum. The residue was purified by flash chromatography on silica gel using a gradient of ethyl acetate and petroleum ether to give 8-chloro-3-propyl-[1 ,2,4]triazolo[4,3-a]pyrazine 20 g (53%) .
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