Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 4774-14-5, name is 2,6-Dichloropyrazine, A new synthetic method of this compound is introduced below., name: 2,6-Dichloropyrazine
A mixture of 2,6-diehloro- pyrazine (1.2 g, 13.4 mmol, I eq) and 35 mL acetonitrile was combined in a heavy wall pressure vessel followed by the addition of 40percent dimethyl amine (14.7 mmol, 1.1 eq) and K2CO3 (16.1 mmol, 1.2 eq) and purged with argon. The pressure vessel was capped and and heated at 900 °C for 4hr (monitored by TLC/HPLC). The reaction mixture was then cooled to ambient temperature, transferred to a round bottom flask and concentrated in vacuo. The residue was treated with 20 mL of Milli-Q water and the aqueous layer was extracted several times with dichloromethane using a separatory funnel. The combined organic layers were dried with anhydrous sodium sulfate and concentrated in vacuo. The product 2 was purified by column chromatography on silica gel (200-400 mesh) using ethyl acetate: hexane (1 : 1 v/v) eluent. Product 11-2 was obtained as white solid (1.1 g) in 60percent (gravimetric) yield, with an apparent HPLC (tr/purity): 1 8.4 mm, > 90percent (HPLC method A); (EST) m/z (MeOH): 158.10 (MH?).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.