Electric Literature of 36070-80-1, The chemical industry reduces the impact on the environment during synthesis 36070-80-1, name is 5-Chloropyrazine-2-carboxylic acid, I believe this compound will play a more active role in future production and life.
General procedure: A solution of compound 10 (216 mg, 1.36 mmol)in SOCl2 was heated to reflux overnight. The excess SOCl2 wasremoved by vacuum distillation. The residue was dissolved in CH2-Cl2 and carefully treated with a solution of 2-amino-6-methylpiridine(739 mg, 6.83 mmol) and NEt3 (275 mg, 2.7 mmol) in CH2Cl2.The mixture was stirred at rt overnight. After the reaction wascompleted, the mixture was extracted with CH2Cl2, washed withwater, brine, and dried over Na2SO4. The organic phase was concentratedin vacuo and the residue was recrystallized from 2-propanolto give compound 11a as a yellow solid (181 mg, 53%).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Chloropyrazine-2-carboxylic acid, other downstream synthetic routes, hurry up and to see.