Application of 1111638-10-8, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1111638-10-8 as follows.
To a solution of 3-chloro-5H-pyrrolo[2,3-b ]pyrazine (300 mg, 1.95 mmol) in2-methyltetrahydrofuran (10 mL) was added NIS (543 mg, 2.34 mmol), and the reaction mixturewas stirred at rt for 1 h. Saturated aqueous sodium thiosulfate (50 mL) was added to quench thereaction, and the resulting mixture was partitioned. The aqueous layer was extracted with EtOAc(50 mL x 2). The combined organic phases were washed with saturated brine (80 mL), driedover anhydrous Na2S04, filtered, and the filtrate was concentrated in vacuo to give the titlecompound as a yellow solid (546 mg, 100 %).MS (ESI, pos. ion) m/z: 280.2 [M+Ht.
According to the analysis of related databases, 1111638-10-8, the application of this compound in the production field has become more and more popular.