In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 486460-21-3, name is 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below. Application In Synthesis of 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine
2-(2,4-Dichlorophenyl)-3-cyano-4-methylsulfonylethyl-6-methylpyridine(Compound III, 0.53 g, 1.38 mmol), DIPEA (0.53 g, 4.14 mmol)Soluble in 10ml DMF,After heating to 60 C for 2.5 h, add 3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-alpha]pyrazine (0.53 g, 2.76 mmol),The temperature was raised to 90 C and stirred for 5 h. The reaction solution was added to 20 ml of water and extracted with EA (10 ml×2).The organic phases were combined, dried over anhydrous sodium sulfate and suction filtered.Concentrated column (CH2Cl2/MeOH)A pale yellow oil was obtained in 0.47 g, yield 71%.
The synthetic route of 486460-21-3 has been constantly updated, and we look forward to future research findings.