Related Products of 55557-52-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 55557-52-3 name is 3-Chloropyrazine-2-carbonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
2-Cyano-3-chloropyrazine (1.5 g, 10.8 mmol) and Raney-Ni (50% slurry in water, 0.5 g) were added to 15 mL of glacial acetic acid under nitrogen for three times.Stir at 50 C overnight under a hydrogen atmosphere of 3 atm. After the reaction is complete, it is filtered.The filtrate was concentrated and the residue dissolved in ethyl acetate.Dry over anhydrous sodium sulfate, concentrate,The pale yellow oil was separated by a silica gel column (0.82 g).The yield was 53%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Chloropyrazine-2-carbonitrile, and friends who are interested can also refer to it.