Adding a certain compound to certain chemical reactions, such as: 939412-86-9, name is (3-Chloropyrazin-2-yl)methanamine hydrochloride, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 939412-86-9, Computed Properties of C5H7Cl2N3
3-Oxo-cyclobutanecarboxylic acid (3-chloro-pyrazin-2-ylmethyl)-amide: 3-Oxo-cyclobutanecarboxylic acid 2,5-dioxo-pyrrolidin-1-yl ester (284 mg, 1.35 mmol), C-(3-chloro-pyrazin-2-yl)-methylamine hydrochloride salt (243 mg, 1.35 mmol), and NaHCO3 (298 mg, 3.55 mmol) were dissolved in THF (2.0 mL) and water (2.0 mL) and the reaction was stirred at rt. After 30 min, the layers were allowed to separate and the aqueous layer was removed. The aqueous layer was back extracted with EtOAc. The organics were dried over MgSO4, filtered, and concentrated in vacuo to provide the title compound as a waxy pale yellow solid. 1H NMR (400 MHz, DMSO-d6) delta 3.10-3.27 (m, 5H), 4.56 (d, 2H, J=5.6 Hz), 8.44 (d, 1H, J=3.2 Hz), 8.63 (d, 1H, J=2.4 Hz), 8.73 (t, 1H, J=5.2 Hz).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, (3-Chloropyrazin-2-yl)methanamine hydrochloride, and friends who are interested can also refer to it.