Electric Literature of 74290-69-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 74290-69-0, name is 5-Bromo-6-methylpyrazin-2-amine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.
To a solution of 5-bromo-6-methylpyrazin-2-amine (300 mg, 1.6 mmol, 1.0 eq) in NMP (12 mL) was added CuCN (287 mg, 3.2 mmol, 2.0 eq). The suspension was heated at 200 C for 1 h in microwave. The reaction mixture was cooled to 25 C, mixed with water (20 mL), NH3.H2O (10 mL) and extracted with EA (10 mL x 3). The combined organic layers were washed with brine (10 mL), dried over anhydrous Na2S04 and concentrated. The residue was purified via flash chromatography to afford 5-amino-3-methylpyrazine-2- carbonitrile as a brown solid (210 mg, 98%).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Bromo-6-methylpyrazin-2-amine, other downstream synthetic routes, hurry up and to see.