Synthetic Route of 14508-49-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 14508-49-7, name is 2-Chloropyrazine, This compound has unique chemical properties. The synthetic route is as follows.
The 2-chloropyrazine (18 ml, 200 mmol) 1a is added to the 2-(diphenylmethyleneamino)acetic acid ethyl ester(51 g, 190 mmol) with a solution of cesium carbonate (6.5 g, 20 mmol) in N,N-dimethyl formamide (250 ml), The reaction was heated to 65 C for 48 hours. The reaction is cooled down to the room temperature, the addition of water (200 ml), ethyl acetate (400 ml × 2) extraction, the combined organic phase with water (500 ml × 2) washing, drying with anhydrous sodium sulfate, filtered and concentrated, the residue by silica gel column chromatography [petroleum ether/ethyl acetate (v/v)=5/1] purification, to give the title compound 1b (48g, 69% yield) as a brown oil.
The chemical industry reduces the impact on the environment during synthesis 2-Chloropyrazine. I believe this compound will play a more active role in future production and life.