In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 121246-96-6 as follows. Application In Synthesis of 3-Chloropyrazine-2-carbaldehyde
Add in pressure reactor3-Chloro-2-carbaldehyde pyrazine (II)(0.71 g, 5 mmol) and dioxane (20 mL),Ammonia (1.7g, 0.1mol) was added with stirring and then added4- (Pyridin-2-yl-Aminocarbonyl) benzeneboronic acid(III) (2.42 g, 10 mmol),Acetylacetonate dicarbonyl rhodium(0.26 g, 1 mmol) and water 4 mL.The reactor closed, gradually warming to 80 ~ 90 degrees,The reaction 16-18 hours, TLC detection, the reaction was completed.Concentration under reduced pressure, the residue was dissolved with methylene chloride,Saturated sodium bicarbonate and water were washed in turn, dried over anhydrous sodium sulfate.Concentrated to give a tan oil,Column chromatography with ethyl acetate and petroleum ether (1: 2 by volume) gave a white solid4- [amino (3-chloro-2-pyrazinyl)Methyl] -N- (2-pyridyl)Benzamide(IV) 1.38 g, 81.2% yield
According to the analysis of related databases, 121246-96-6, the application of this compound in the production field has become more and more popular.