Some common heterocyclic compound, 21279-64-1, name is 5-Chloropyrazine-2-carboxamide, molecular formula is C5H4ClN3O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Formula: C5H4ClN3O
Example 14 (compound No. 234)2,2,2-Trifluoro-1 -(trifluoromethyl)ethyl 4-[2-(5-carbamoylpyrazin-2-ylamino)ethyl]piperidine- 1 -carboxylate14.1 . ie f-Butyl 4-[2-(5-carbamoylpyrazin-2-ylamino)ethyl]piperidine-1 -carboxylate; A mixture of 1.12 g (7.15 mmol) of 5-chloropyrazine-2-carboxamide, 1.95 g (8.58 mmol) of ie f-butyl 4-(2-aminoethyl)piperidine-1 -carboxylate and 1 .18 g (8.58 mmol) of potassium carbonate in 1 .4 ml of dimethyl sulphoxide is heated during 5 hours at 100C under an argon atmosphere and with stirring. After cooling to ambient temperature, 25 ml of ethyl acetate and 25 ml of water are added. The organic phase is separated by settling and washed 3 times with 25 ml of water and then 25 ml of a saturated aqueous sodium chloride solution. It is dried over sodium sulphate and evaporated to dryness. The residue is purified by chromatography on silica gel, elution being carried out with a 97:3, then 95:5 and 93:7 mixture of dichloromethane and methanol, in order to obtain 1 .99 g (5.69 mmol) of product in the form of a light-yellow paste.1H NMR (CDCI3, delta ppm, 200 MHz): 8.65 (s, 1 H), 8.10 (s, 1 H), 7.55 (m, 1 H), 5.75 (m, 1 H), 4.85 (m, 1 H), 4.15 (m, 2H), 3.45 (m, 2H), 2.75 (t, 2H), 1 .80-1 .60 (m, 5H), 1 .50 (s, 9H), 1 .35-1 .10 (m, 2H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 21279-64-1, its application will become more common.