Reference of 2423-65-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2423-65-6, name is Pyrazine 1-oxide belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.
General Procedure 2:; Palladium-Catalyzed Direct Arylation with Aryl Chlorides and Bromides.; To a dried flask was added the diazine N-oxide (1.0 to 3.0 equiv.), K2CO3 (2.0 equiv.), Pd(OAc)2 (5 mol %) and HP(t-Bu)3BF4 (15 mol %). If the arylhalide is a solid, it is added at this point (1.0 equiv.). The flask and its contents were then purged under nitrogen for 10 minutes. If the aryl halide is a liquid, it is added via syringe after purging, followed by the addition of degassed dioxane (to produce a reaction concentration of 0.3 M relative to the halide). The reaction mixture was then heated at 110 C. until the reaction was complete, after which the volatiles were removed under reduced pressure and the residue was purified via silica gel column chromatography.; 2-(Naphthalen-1-yl)pyrazine N-oxide (Table 4, entries 2, 13 and 14) Synthesised according to general procedure 2 employing the corresponding aryl bromide and chloride. Purification via silica gel column chromatography using 100% DCM then a mixture of 10% Acetone/DCM gave a brown oil, 89% from the bromide and 60% from the chloride. 1H NMR (300 MHz, CDCl3, 293K, TMS): delta 8.61 (1H, s), 8.48 (1H, d, J=3.9 Hz), 8.26 (1H, d, J=4.2 Hz), 8.00 (1H, d, J=7.8 Hz), 7.93-7.87 (1H, m), 7.59-7.37 (5H, m). 13C NMR (75 MHz, CDCl3, 293K, TMS): 150.1, 147.1, 145.7, 134.8, 133.9, 131.5, 131.3, 129.2, 128.9, 127.6, 127.0, 125.7, 125.3. HRMS calculated for C14H10N2O1 (M+) 222.0793; Found: 222.0775. IR (vmax/cm-1): 3057, 3010, 2923, 2853, 1578, 1301, 873, 801, 776.
The synthetic route of Pyrazine 1-oxide has been constantly updated, and we look forward to future research findings.