Related Products of 5521-55-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 5521-55-1 name is 5-Methylpyrazine-2-carboxylic acid, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a 250 ml four-necked flask was added 13.8 g of 5-methylpyrazine-2-carboxylic acid and 35.7 g of thionyl chloride, and the mixture was heated with stirringReflux reaction 2h, stop heating, vacuum distillation out of excess thionyl chloride, to be evaporated to dry, cooled to room temperature. The residue is dissolved138 g of dichloromethane, and then 20.4 g of p-aminoethylbenzenesulfonamide was added, and 30.4 g of triethylamine was slowly added with stirring,And then stirred at room temperature for 12 h. Filter, and with a small amount of dichloromethane rinse, dry, the filter cake into the water, with hydrochloric acidPH = 1, stirring for 20min, filtered and washed with water to neutral, the resulting solid at 60 ~ 70 for 12h, you can get29.5 g of a white solid product, 2- [4-aminosulfonyl-phenyl] -ethyl-5-methylpyrazine formamide, yield 92.2%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-Methylpyrazine-2-carboxylic acid, and friends who are interested can also refer to it.