Synthetic Route of 143591-61-1,Some common heterocyclic compound, 143591-61-1, name is 3-Bromo-8-chloroimidazo[1,2-a]pyrazine, molecular formula is C6H3BrClN3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Intermediate Example 3-1 : Preparation of 3-bromo-8-methylsulfanyl- imidazo[1 ,2-a]pyrazine To a stirred solution of 3-bromo-8-chloro-imidazo[1 ,2-a]pyrazine ( 1 1 .63 g, 50 mmol) in 120 mL NMP is added at -15C under stirring sodium thiomethylate (3.52 g, 50 mmol) After stirring for 4 h the mixture is left to come to rt and stirred overnight. 500 mL of water are added and the light brown solid is filtered off, washed and dried in vaccuo to yield 8.81 (72 %) of the title compound. UPLC-MS: RT = 0.93 min; m/z 245.1 [MH+]; required MW = 244.1.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Bromo-8-chloroimidazo[1,2-a]pyrazine, its application will become more common.