Adding a certain compound to certain chemical reactions, such as: 875781-43-4, name is 2-Bromo-5H-pyrrolo[2,3-b]pyrazine, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 875781-43-4, SDS of cas: 875781-43-4
To a solution of 2-bromo-5H-pyrrolo [2,3-b] pyrazine (3.1 g, 16 mmol)Of 1,4-dioxane (20 mL)Phosphorus oxychloride (2.27 mL, 24.1 mmol) was added to the solution andTriethylamine (220 [mu] L, 1.58 mmol)110 C for 6 hours,(50 mL x 3), dried over anhydrous sodium sulfate, and the mixture was concentrated and beaten (petroleum ether / ethyl acetate (v / v), and the mixture was stirred at room temperature (7 mL) ) = 2/1), filtration,Dried to give 1.3 g of a gray solid in 54% yield.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Bromo-5H-pyrrolo[2,3-b]pyrazine, and friends who are interested can also refer to it.