Electric Literature of 6966-01-4, These common heterocyclic compound, 6966-01-4, name is Methyl 3-amino-6-bromopyrazine-2-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a 250 ml reaction flask add 43g III, 43 ml 98.3% concentrated sulfuric acid, stirring. – 20 – 0 C lower, adding 25.6g sodium nitrite, canada finishes rose to 55 – 60 C, thermal insulation stirring for about 30min to the raw basic reaction end. The reaction liquid dropping 430g ice water, canada finishes insulation stirring for about 1.5h to the reaction is complete. Filtering, the filter cake 50 C drying by blowing 6h, get 37.6g orange solid IV, yield 87%.
The synthetic route of 6966-01-4 has been constantly updated, and we look forward to future research findings.