Continuously updated synthesis method about Ethyl imidazo[1,2-a]pyrazine-2-carboxylate

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 77112-52-8.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 77112-52-8, name is Ethyl imidazo[1,2-a]pyrazine-2-carboxylate, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of Ethyl imidazo[1,2-a]pyrazine-2-carboxylate

Step 2: 5, 6,7, 8-Tetrahydroimidazo [1,2-a] pyrazine-2-carboxylic acid ethyl ester, Hydrochloride :; 0.46 M HCI-EtOH (169 mL) and 10% Pd-C (50% wet) (1.37 g) were added to the EtOH (546 mL) solution of imidazo [1,2-a] pyrazine-2-carboxylic acid ethyl ester (13.7 g). The mixture was hydrogenated under H2 at 40 psi at room temperature for 15 h. The reaction mixture was filtered and Pd-C was washed with EtOH. The filtrate was concentrated under reduced pressure. The residue was applied to silica gel column chromatography, then the column was eluted with CHCI3-MeOH (9/1- 2/1). The titled compound was obtained as brown crystals Yield : 10.4 g, 63%. ‘H NMR (CDCI3) 8 d 1.38 (t, 3H, J = 7.1 Hz), 3.90 (t, 2H, J = 5.7 Hz), 4.40 (q, 2H, J= 7.1 Hz), 4.59 (t, 2H, J= 5.7 Hz), 4.80 (s, 2H), 8.20 (s, 1H).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 77112-52-8.