Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 69214-33-1, name is 8-Chloroimidazo[1,2-a]pyrazine, A new synthetic method of this compound is introduced below., Formula: C6H4ClN3
Step 2: 3-Bromo-8-chloroimidazo[l,2-a]pyrazine[0314] A solution of 8-chloroimidazo[l,2-a]pyrazine (15g, 97.4 mmol) in DCM (300 mL) was treated with NBS (19. Ig, 108 mmol) at room temperature and stirred at this temperature for overnight. The reaction was monitored by TLC. After this time, the resulting solution was diluted with 200 mL DCM and washed with saturated solution of Na2CO3 (2×150 mL), and brine (1×150 mL). Organic layer was dried over Na2SO4, filtered and concentrated in vacuo to give the crude product that was purified by a silica gel column chromatography eluted with ethyl acetate in petroleum ether (1:2) to give 3-bromo-8-chloroimidazo[l,2-a]pyrazine (9.5g, 42%) as yellow solid. 1H NMR (400 MHz, CDCl3) delta 8.04 (IH, d, J = 4.6 Hz), 7. 84 (s, IH), 7.82 (2H, d, J = 4.6 Hz).
The synthetic route of 69214-33-1 has been constantly updated, and we look forward to future research findings.