Some common heterocyclic compound, 33332-28-4, name is 2-Amino-6-chloropyrazine, molecular formula is C4H4ClN3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C4H4ClN3
To 2-amino-6-chloropyrazine (3.1 mmol), l-Boc-5-fluoroindole-2-boronic acid (3.1 mmol), Pd(PPh3)4, (100 mg, 0.0865 mmol) and K2CO3 (7.2 mmol) were added 7 mL MeCN and 3 mL H2O and the mixture was heated in a sealed tube at 80 0C for 1 h. The water layer was separated and the organic phase was dried over MgSO4. Filtration and removal of the solvent gave 1.05 g of the title compound.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 33332-28-4, its application will become more common.