55557-52-3, name is 3-Chloropyrazine-2-carbonitrile, belongs to pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. HPLC of Formula: C5H2ClN3
iv) (+-)-3-[(6R,9aS)-6-(hydroxymethyl)octahydro-2H-pyrido[1,2-a]pyrazin-2-yl]pyrazine-2-carbonitrile (+-)-(6R,9aS)-Octahydro-2H-pyrido[1,2-a]pyrazin-6-ylmethanol (500 mg, 2.93 mmol) was dissolved in THF (7 mL) and Et3N (2.03 mL, 14.7 mmol). 3-Chloropyrazine-2-carbonitrile (573 mg, 4.11 mmol) was added with stirring, and the reaction was stirred overnight at 35 C. The reaction mixture was then diluted with DCM and washed with water. The organic phase was purified by column chromatography to yield the desired product (650 mg, 81%). 1H NMR (300 MHz, CDCl3): delta (ppm) 1.40 (m, 1H); 1.69 (m, 4H); 1.82 (m, 1H); 2.21-2.32 (m, 4H); 2.93 (dd, 1H); 3.28 (m, 2H); 3.35 (d, 1H); 3.96 (dd, 1H); 4.34 (d, 1H); 4.48 (d, 1H); 8.02 (d, 1H); 8.26 (d, 1H).
The synthetic route of 55557-52-3 has been constantly updated, and we look forward to future research findings.