Related Products of 63286-28-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 63286-28-2, name is 2-Chloro-3-hydrazinylpyrazine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.
General procedure: To a mixture of compound 8 (1.0 g, 1.30 mmol) and pyridine (5 mL) in anhydrous methanol (13 mL), methyl carbazate (0.434 g, 4.82 mmol) was added under the protecting of N2 and adjusted the pH to 5-6 with acetic acid. After stirring for 17 h at room temperature, the reaction solution was evaporated under reduced pressure. After adding water (10 mL) to the residue and extracted three times with an equal volume of ethyl acetate. The organic phase combined and dried with anhydrous MgSO4, concentrated under reduced pressure to afford crude product, which was further purified with chromatography on silica gel using petroleum ether/ethyl acetate (6:1) as eluant to give a white solid 0.50 g.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Chloro-3-hydrazinylpyrazine, other downstream synthetic routes, hurry up and to see.