Reference of 1053656-22-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1053656-22-6 name is 7-tert-Butyl 2-ethyl 5,6-dihydroimidazo[1,2-a]pyrazine-2,7(8H)-dicarboxylate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a solution of 3.40 g (11.5 mmol) of ethyl 7- (tert-butoxycarbonyl)-5, 6,7, 8- tetrahydroimidazo [1, 2-A] PYRAZINE-2-CARBOXYLATE (Example 10, Step 1) in 60 mL of dichloromethane was added 8.64 ML (17.3 mmol) of 2N methoxy (methyl) amine, and then 1.35 g (13.8 mmol) OF TRIMETHYLALUMINUM was added over 15 min. The reaction was stirred at ambient temperature for 14 h. The reaction was quenched slowly with water, the mixture was extracted with three portions of dichloromethane, and the combined organic layers were washed sequentially with 1N hydrochloric acid, saturated aqueous sodium bicarbonate solution and brine. The organic layer was dried over magnesium sulfate, and concentrated. The residue was purified by flash chromatography on a BIOTAGE system (silica gel, 100% ethyl acetate then 10% methanol in ethyl acetate) to give the title compound as a solid.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 7-tert-Butyl 2-ethyl 5,6-dihydroimidazo[1,2-a]pyrazine-2,7(8H)-dicarboxylate, and friends who are interested can also refer to it.