Some common heterocyclic compound, 36070-75-4, name is 5-Chloropyrazine-2-carbonitrile, molecular formula is C5H2ClN3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C5H2ClN3
EXAMPLE 54 5-((3 ?)-3-{[5-fluoro-6-(2-hydroxyethoxy)-2^yrazolo[1 ,5-a]pyridin-3-ylpyrimidin-4- yl]amino}piperidin-1-yl)pyrazine-2-carbonitrile A mixture of (R)-2-((5-fluoro-6-(piperidin-3-ylamino)-2-(pyrazolo[1 ,5-a]pyridin-3- yl)pyrimidin-4-yl)oxy)ethanol dihydrochloride (Example 40b, 0.050 g, 0.13 mmol), 2- chloro-5-cyanopyrazine (0.025 g, 0.18 mmol) and triethylamine (0.056 mL, 0.4 mmol) in N,N-dimethylformamide (1 .0 mL) was heated in a microwave at 120 C for 2 hours. The reaction mixture was cooled to ambient temperature and ethyl acetate (10 mL) was added. The solution was washed with water (10 mL) and brine (20 mL). The organic layer was separated, dried over anhydrous magnesium sulfate, filtered, and concentrated under reduced pressure. The residue was taken up in dichloromethane (5 mL), the suspension was filtered and dried in vacuo to give the title compound (0.012 g, 19%) as a solid. LRMS (m/z): 476 (M+1 )+. 1H-NMR delta (300 MHz, DMSO-d6): 1 .50 – 1 .98 (m, 4H), 2.00 – 2.17 (m, 1 H), 3.02 (dd, 2H), 3.68 – 3.87 (m, 2H), 4.14 (br. s., 1 H), 4.42 (d, 1 H), 4.50 (d, 2H), 4.75 (br. s., 1 H), 4.93 (d, 1 H), 6.94 – 7.10 (m, 1 H), 7.30 (dd, 2H), 8.32 (d, 1 H), 8.46 (d, 1 H), 8.58 (s, 1 H), 8.80 (d, 1 H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 36070-75-4, its application will become more common.