Adding a certain compound to certain chemical reactions, such as: 77112-52-8, name is Ethyl imidazo[1,2-a]pyrazine-2-carboxylate, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 77112-52-8, Recommanded Product: Ethyl imidazo[1,2-a]pyrazine-2-carboxylate
Step 2: 5, 6,7, 8-Tetrahydroimidazo [1, 2-a] pyrazine-2-carboxylic acid ethyl ester, Hydrochloride : 0.46 M HCI EtOH (169 mL) and 10% Pd-C (50% wet) (1.37 g) were added to the EtOH (546 mL) solution of imidazo [1,2-a] pyrazine-2-carboxylic acid ethyl ester (13.7 g). The mixture was hydrogenated under H2 at 40 psi at room temperature for 15 h. The reaction mixture was filtered and Pd-C was washed with EtOH. The filtrate was concentrated under reduced pressure. The residue was applied to silica gel column chromatography, then the column was eluted with CHCis-MeOH (9/1-2/1). The titled compound was obtained as brown crystals Yield : 10.4 g, 63%. ‘H NMR (CDCI3) d 1.38 (t, 3H, J = 7.1 Hz), 3.90 (t, 2H, J = 5.7 Hz), 4.40 (q, 2H, J = 7.1 Hz), 4.59 (t, 2H, J = 5.7 Hz), 4.80 (s, 2H), 8.20 (s, 1 H).
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Reference:
Patent; WYETH; WO2003/93277; (2003); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem