In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 54608-52-5 as follows. category: Pyrazines
50ml three-necked flask, add 0.2g of compound 6, 15ml of methylene chloride and 15ml of ethyl acetate, after stirring to dissolve,0.3 g of compound 4 and 3 g of T 3 P and 0.75 g of DIPEA were added at 0 C. The system was stirred at 0 C. for 30 min to carry out the reaction until the reaction junctionAfter the beam was added 50ml of dichloromethane and 30ml of water, liquid separation, the organic phase evaporated to give crude compound 7, the crude product is not purified directly down vote;
According to the analysis of related databases, 54608-52-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Guangzhou Wenhao Biological Technology Co., Ltd.; Chen Xinying; Xu Liang; Liu Wenzhong; (7 pag.)CN106831731; (2017); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem