Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 5900-13-0, name is 5-Bromo-3-methoxypyrazin-2-amine, A new synthetic method of this compound is introduced below., Application In Synthesis of 5-Bromo-3-methoxypyrazin-2-amine
3,4-dichlorophenyl-methanesulfonyl chloride (2.4 mmol, 650 mg) was added to a solution of 5-bromo-3-methoxypyrazine-2-ylamine (2 mmol, 410 mg) and pyridine (5 mmol, 411 microliter). The mixture was stirred for 72 hours and then partitioned between ethyl acetate, water and acetic acid. The organic phase was collected and evaporated and the residue was crystallized from ethyl acetate and heptane to afford the intermediate N- (5-bromo-3-methoxypyrazine-2-yl)-3,4-dichlorophenyl-methanesulfonamide (1.1 mmol, 470 mg). This was dissolved in dichloromethane (2 mL), cooled on an ice-bath, and boron tribromide (1 M solution in dichloromethane, 2 mmol) was added. The mixture was stirred for 3 hours, then poured onto NaHC03(s)/ice and stirred for additional 3 hours. The precipitate was collected and dissolved in hot ethanol (99.5%), the mixture was filtered while hot, and water was added to the filtrate. The precipitate was collected to afford the title compound (175 mg, 20%)
The synthetic route of 5900-13-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ACTIVE BIOTECH AB; FRITZSON, Ingela; LIBERG, David; EAST, Stephen; MACKINNON, Colin; PREVOST, Natacha; WO2014/184234; (2014); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem