69214-33-1, name is 8-Chloroimidazo[1,2-a]pyrazine, belongs to pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. name: 8-Chloroimidazo[1,2-a]pyrazine
Example 2 – Synthesis of A/-(3-(8-(3-fluorophenylamino)imidazori,2-a1pyrazin-3- vDphenvDacetamide (Compound 160)3-Bromo-8-chloroimidazo[ 1 ,2-a”|pyrazine[00239] Bromine (1.42 mL, 27.72 mmol) was added to a suspension of 8- chloroimidazo[l,2-a]pyrazine (2.83 g; 18.48 mmol) in glacial acetic acid (55 mL) and the resulting mixture was stirred at room temperature for 16 hours. The reaction mixture was then concentrated in vacuo and the resulting residue was taken up in DCM/methanol (9:1), subsequently washed with saturated aqueous sodium bicarbonate solution (2 x 70 mL), IM sodium thiosulfate (70 mL), brine (70 mL), dried (MgSO4) and concentrated in vacuo to give the title compound (3.397 g, 79%) as a light brown/golden solid. 1H NMR (d6-DMSO): 8.49(IH, d, J4.6), 8.04 (IH, s), 7.89-7.84 (IH, br m).[00240] The use of Br2/acetic acid could give partial bromination, along with partial chloride displacement by bromide, giving a mixture of 4 possible products A:B:C:D in a1 :2: 1 : 1 mixture. The dihalo species C and D were separated from the monohalo analogues A and B so the final compound was a mixture of two dihaloimidazopyrazines. This product composition could alter on a larger scale.X = Cl, A X = Cl, CX = Br, B X = Br, DA:B:C:D = 1 :2:1 :1
The synthetic route of 69214-33-1 has been constantly updated, and we look forward to future research findings.