Some common heterocyclic compound, 59489-71-3, name is 2-Amino-5-bromopyrazine, molecular formula is C4H4BrN3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 59489-71-3
Preparation 10: 2-Bromo-5-iodopyrazineTo a solution of 5-bromopyrazin-2-amine (25.95 g, 147.13 mmol) in 1 ,2-dimethoxyethane (500 ml_) was added cesium iodide (38.75 g, 147.13 mmol), copper (I) iodide (8.52 g, 44.74 mmol) and iodine (18.93 g, 74.57 mmol). Isoamyl nitrite (120 ml_, 894.8 mmol) was then added dropwise via a dropping funnel and the reaction mixture was heated at 60 C for 1 hour. After this time, the mixture was cooled to room temperature and diluted with ethyl acetate (200 ml_), washed with ammonium chloride (sat. aq .200 ml_), then sodium thiosulphate (sat. aq.3 x 200 ml_). The organic layer was dried over MgS04, filtered and the solvent was evaporated under reduced pressure. The crude product was purified by silica column (heptane : ethyl acetate, 100:0 to 85:15) to give the title compound as a off-white solid (35.38 g).LCMS (run time = 5 minutes, System D): Rt = 2.09 minutes.H NMR (400 MHz, CDCI3): delta = 8.65 (s, 1 H), 8.50 (s, 1 H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 59489-71-3, its application will become more common.