Electric Literature of 109838-85-9, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 109838-85-9 as follows.
To a mixture of scheme 5-8 compound S3 (22 g, 0.10 mol) and PPh3 (82.3 g, 0.31 mol) in dry dichloromethane (200 mL) was added perbromomethane (86.95 g, 0.26 mol) in dry dichloromethane (50 mL) dropwise at 0 oC. The reaction was stirred at room temperature overnight and concentrated under reduced pressure to give a residue that was purified by silica gel chromatography (petroleum ether: ethyl acetate=80:1) to afford the title compound (23 g, 66.7% yield) as a yellow oil.
According to the analysis of related databases, 109838-85-9, the application of this compound in the production field has become more and more popular.