Related Products of 1082843-70-6,Some common heterocyclic compound, 1082843-70-6, name is 3,5-Dibromo-2-chloropyrazine, molecular formula is C4HBr2ClN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A solution containing 3,5-dibromo-2-chloropyrazine (1.03 g, 3.60 mmol) and tert-butyl N-[(3S)-3-piperidyl]carbamate (600 mg, 3.00 mmol) in methyl sulfoxide 5.0 mL was heated 85C. The reaction was quenched with water then extract with EtOAc. The organic layers wasdried with sodium sulfate, filtered, and concentrated in vacuum. The crude product was purified by flash chromatography (EtOAc/Heptane eluted at 35%EtOAc) to give the desired product 350 mg 30% yield. MS (ESI) m/z: 393.2.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3,5-Dibromo-2-chloropyrazine, its application will become more common.