Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 36070-80-1, name is 5-Chloropyrazine-2-carboxylic acid, A new synthetic method of this compound is introduced below., SDS of cas: 36070-80-1
5-Hydroxypyrazine-2-carboxylic acid [CAS RN: 34604-60-9] (500 mg, 3.57 mmol,1.0 eq) was treated with thionyl chloride (3.90 mL, 53.5 mmol, 15 eq) and 0.04 mL DMF. Then, the reaction mixture was heated to reflux temperature for 4 h. On cooling, the volatile components were removed in vacuo. The crude material remaining was diluted with toluene and the resulting solution was concentrated by the use of a rotary evaporator. This procedure was repeated two more times.Then, the remaining material was treated with 4 mL DMF and with 2-methoxy-N- methylethanamine [CAS-RN: 38256-93-8] (795 mg, 8.92 mmol, 2.5 eq). The reaction mixture was stirred at rt overnight. The volatile components were removed in vacuo and the crude material was purified via preparative MPLC (Biotage Isolera; 25 g SNAP cartridge: hexane -> hexane/ethyl acetate 2/1 ->ethyl acetate ) to give 290 mg (34% yield of theory) of the title compound.UPLC-MS (Method 1): R = 0.76 mm; MS (EI0): m/z = 230 [M+H].
The synthetic route of 36070-80-1 has been constantly updated, and we look forward to future research findings.