Synthetic Route of 143591-61-1, A common heterocyclic compound, 143591-61-1, name is 3-Bromo-8-chloroimidazo[1,2-a]pyrazine, molecular formula is C6H3BrClN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
This solid was suspended in 1 : 1 dichloromethane/methanol (150 ml) and treated with solid sodium methoxide (9.8 g, 0.18 mol). The resulting mixture was then stirred at 40C for 2 h. The reaction was cooled, diluted with water (750 ml) then extracted with dichloromethane (600 ml). The organics were dried over anhydrous magnesium sulphate, filtered and concentrated to give 3-BROMO-8- METHOXYIMIDAZO [L, 2-A] PYRAZINE as a white solid (24.5 g, 89% over 2 steps):
The synthetic route of 143591-61-1 has been constantly updated, and we look forward to future research findings.