Adding a certain compound to certain chemical reactions, such as: 681249-57-0, name is 2-(Trifluoromethyl)-5,6,7,8-tetrahydro[1,2,4]triazolo[1,5-a]pyrazine, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 681249-57-0, Product Details of 681249-57-0
A suspension of Rac-BINAP-Pd-G3 precatalyst (46.5 mg, 0.047 mmol), 2- (trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyrazine (90 mg, 0.469 mmol), (R)- tert-butyl 3-(4-bromo-2-(N,N-dibenzylsulfamoyl)-3-(2-(4-methoxybenzyl)-2H-tetrazol-5- yl)phenylsulfonamido)pyrrolidine-1-carboxylate (REFERENCE EXAMPLE 9) (200 mg, 0.235 mmol) and Cs2CO3 (229 mg, 0.704 mmol) in DME (4 mL) was degassed for 20 min. The reaction mixture was heated to 80 C for over night. The reaction mixture was cooled down to rt, then was chromatographed over silica gel (0-10% MeOH in DCM as eluent) to give the title product. LCMS [M+H]+ 964.2.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(Trifluoromethyl)-5,6,7,8-tetrahydro[1,2,4]triazolo[1,5-a]pyrazine, other downstream synthetic routes, hurry up and to see.