Related Products of 5780-66-5,Some common heterocyclic compound, 5780-66-5, name is Pyrazine-2-carbaldehyde, molecular formula is C5H4N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A mixture of pyrazine-2-carboxaldehyde (1.1 g, 10 mMol), sulphur powder (0.6 g, 18 mMol), and piperidine (3 mL) was stirred at 110° C for 2 hrs. The resultant dark brown mixture was left to stand overnight and then was poured into cold water. The solid was collected by filtration and purified by column chromatography (silica gel, dichloromethane) to give 400 mg of crude thio piperidyl amide as a yellow solid. This was dissolved in methanol (5 mL) and hydrazine hydrate (0.1 mL) was added to the solution. The mixture was stirred at room temperature for 1 hr. More hydrazine hydrate (0.5 mL) was added and the mixture was stirred for 1 hr more. After neutralisation with glacial acetic acid the mixture was extracted with ethyl acetate and dried over MgS04. Isatin (300 mg) and glacial acetic acid (1 mL) were added to the solution and the reaction mixture was heated under reflux overnight. The solvent was evaporated in vacuo and the residue was recrystallised from acetonitrile to give the desired product (130 mg) as a beige solid.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Pyrazine-2-carbaldehyde, its application will become more common.