These common heterocyclic compound, 88625-24-5, name is 5-Chloropyrazine-2-carbaldehyde, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C5H3ClN2O
To a solution of 5-chloropyrazine-2-carbaldehyde (500 mg, 3.51 mmol) in CH2Cl2 (10 mL) was added (diethylamino)difluorosulfonium tetrafluoroborate (2.0 g, 8.77 mmol) and triethylamine trihydrofluoride (0.57 mL, 3.51 mmol). The reaction mixture was stirred for 18 hours at ambient temperature. The reaction mixture was diluted with water and was extracted with CH2Cl2. The organic layer was dried over anhydrous MgSO4, filtered and concentrated under reduced pressure. Purification of the residue via column chromatography (SiO2, heptane:ethyl acetate 0~65%) gave the title (200 mg, 1.22 mmol, 35% yield). 1H NMR (500 MHz, DMSO-d6) delta ppm 9.00 – 8.93 (m, 1H), 8.86 (q, J = 1.1 Hz, 1H), 7.17 (t, J = 54.0 Hz, 1H); MS (ESI+) m/z 186 (M+Na)+.
The synthetic route of 5-Chloropyrazine-2-carbaldehyde has been constantly updated, and we look forward to future research findings.